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Short-term toxicity to fish

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Description of key information

The test substance is not acutely toxic to fish in the range of solubility. 

Key value for chemical safety assessment

Additional information

Three studies on the acute toxicity to fish with O,O,O-triphenyl thiophosphate are available.

In the key study (RCC 2002) which was performed according to GLP, zebra-fish (Brachydanio rerio) were exposed for 96-h to the test item at concentrations of 0 (control, solvent control) and saturation concentration (undiluted filtrate with a nominal loading rate of 100 mg/L) under static conditions. The 96-h LC50 was higher than the saturation concentration. The NOECs, based on mortality and sublethal effects, were ≥ the saturation concentration, respectively. Sublethal effects were not observed.

In addition, the 96-h acute toxicity to zebra-fish (Brachydanio rerio) was determined in a supportive non-GLP study (Ciba-Geigy, 1988). In this study test organisms were exposed to test item at nominal concentrations of 0 (control, solvent control), 1.8, 3.2, 5.8, 10, 18, 32, 58 and 100 mg/L for 96-h under static conditions. The 96-h LC50 was 83 mg/L. The LC0 was 18 mg/L. However, high vehicle concentration was used and undissolved test item was observed in concentrations above 18mg/L and observed adverse effect could relate to this fact.

 

A supporting study conducted according to OECD guideline 203 with O,O,O-triphenylphosphorotioate in a lower purity (purity > 25%) is available (RCC Umweltchemie AG, 1997). A water accommodated fraction was prepared for the investigation. Zebra fish were used as test organisms and the LC50 after 96 hours of semi-static exposure was determined to be > saturation concentration (undiluted filtrate of a nominal loading rate of 100 mg/L). No effects were observed up to highest tested concentration and saturation concentration, respectively.

Thus, it can be concluded that the test substance is not acutely toxic to fish at the range of solubility.