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Diss Factsheets
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EC number: 201-853-3 | CAS number: 88-72-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Comparable to guideline study with acceptable restrictions, Basic data given
- Principles of method if other than guideline:
- - in analogy with the OECD proposal (1979) long-term toxicity test were performed on crustaceans
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-Nitrotoluene
- Analytical purity: > 99.5%
- Supplier: Fluka - Test organisms (species):
- Daphnia magna
- Duration:
- 21 d
- Dose descriptor:
- LC50
- Effect conc.:
- 7.5 mg/L
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 2.6 mg/L
- Basis for effect:
- other: mortality and behavior
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 2.5 mg/L
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.5 mg/L
- Basis for effect:
- reproduction
- Executive summary:
Canton et al. (1985) determined the following values for Daphnia magna after a semi-chronic exposure period (21 days) with 2-nitrotoluene in analogy with the OECD proposal (1979) long-term toxicity test were performed on crustaceans: LC50: 7.5 mg/L, EC50 (mortality and behavior): 2.6 mg/L, EC50 (reproduction): 2.5 mg/L and NOEC (reproduction): 0.5 mg/L.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- National Guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: protocol of the Dutch Standards Organisation NEN 6502 (1980)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-Nitrotoluene
- Analytical purity: > 99.5%
- Supplier: Fluka - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - all daphnids used were <24 h old at the start of the experiment
- during the test daphnids were fed with Chlorella pyrenoidosa 3x10E8 cells l-1 day-1 - Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 21 d
- Hardness:
- 200 mg/l CaCO3
- Test temperature:
- 20 ± 0.5°C
- pH:
- 8.4 ± 0.1°C
- Dissolved oxygen:
- synthetic test medium saturated with air prior to use
- Details on test conditions:
- - illumination: 12 h/d
- Duration:
- 21 d
- Dose descriptor:
- IC50
- Effect conc.:
- 7.36 mg/L
- Basis for effect:
- immobilisation
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 9.93 mg/L
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 9.93 mg/L
- Basis for effect:
- growth
- Executive summary:
Deneer et al. (1989) carried out a study on Daphnia magna, in semi-static test conditions, following the protocol of the Dutch Standards Organization NEN 6502 (1980). Test organisms were fed with 3·108cells/l·day of Chlorella pyrenoidosa. All daphnids used were < 24 h old at the start of the experiments. A log(21d-LOEC) of 1.86 µmol/l (21d-LOEC of 9.9 mg/l) was determined for 21-d test as the lowest concentration tested that significantly decreased the length and the intrinsic growth rate of Daphnia magna population.
Referenceopen allclose all
EU Risk Assessment (2008):
Canton et al. (1985) determined the following values for Daphnia magna after a semi-chronic exposure period: 2.5 mg/l as the concentration that reduced the reproduction in a 50% and, 0.5 mg/l as the no observed inhibition of reproduction.
EU RAR (2008):
Deneer et al. (1989) carried out a study on D. magna, in semi-static test conditions, following the protocol of the Dutch Standards Organization NEN 6502 (1980). Test organisms were fed with 3·108cells/l·day of Chlorella pyrenoidosa. All daphnids used were < 24 h old at the start of the experiments. A log(21d-LOEC) of 1.86 µmol/l (21d-LOEC of 9.9 mg/l) was determined for 21-d test as the lowest concentration tested that significantly decreased the length and the intrinsic growth rate of Daphnia magna population.
Description of key information
For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".
Canton et al. (1985) determined the following values for Daphnia magna after a semi-chronic exposure period (21 days) with 2-nitrotoluene in analogy with the OECD proposal (1979) long-term toxicity test were performed on crustaceans: LC50: 7.5 mg/L, EC50 (mortality and behavior): 2.6 mg/L, EC50 (reproduction): 2.5 mg/L and NOEC (reproduction): 0.5 mg/L.
Deneer et al. (1989) carried out a study on Daphnia magna, in semi-static test conditions, following the protocol of the Dutch Standards Organization NEN 6502 (1980). Test organisms were fed with 3·108cells/l·day of Chlorella pyrenoidosa. All daphnids used were < 24 h old at the start of the experiments. A log(21d-LOEC) of 1.86 µmol/l (21d-LOEC of 9.9 mg/l) was determined for 21-d test as the lowest concentration tested that significantly decreased the length and the intrinsic growth rate of Daphnia magna population.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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