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Diss Factsheets
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EC number: 201-853-3 | CAS number: 88-72-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- other: EU Risk Assessment
- Adequacy of study:
- other information
- Reliability:
- other: EU Risk Assessment
- Rationale for reliability incl. deficiencies:
- other: no reliability is given as this is a summary entry for the EU RAR
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- European Union Risk Assessment Report - 2-Nitrotoluene
- Author:
- European Commission - European Chemicals Bureau
- Year:
- 2 008
- Bibliographic source:
- Office for Official Publications of the European Communities
- Reference Type:
- publication
- Title:
- Etude analytique, toxicologique et biochimique des dérivés mononitrés du toluene
- Author:
- Ciss M
- Year:
- 1 978
- Bibliographic source:
- Dissertation, Université René Descartes de Paris, Serie E
- Reference Type:
- publication
- Title:
- Etude toxicologique des nitrotoluènes: Toxicité à long terme
- Author:
- Ciss M, Huyen N, Dutertre H, Phu-Lich N and Truhaut R
- Year:
- 1 980
- Bibliographic source:
- Dakar Med 25(4): 293-302
- Reference Type:
- publication
- Title:
- SIDS dossier on the OECD HPV chemical 2-nitrotoluene
- Author:
- KemI
- Year:
- 1 994
- Bibliographic source:
- KemI
Materials and methods
- Principles of method if other than guideline:
- EU Risk Assessment
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-nitrotoluene
- EC Number:
- 201-853-3
- EC Name:
- 2-nitrotoluene
- Cas Number:
- 88-72-2
- Molecular formula:
- C7H7NO2
- IUPAC Name:
- 1-methyl-2-nitrobenzene
Constituent 1
Results and discussion
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
EU Risk Assessment (2008)
Oral - Rats
Within the framework of a study on subchronic and reproductive toxicity, Wistar rats (10 animals/sex/group weighing about 200 g) were administered 0 and 200 mg/kg b.w. of 2- nitrotoluene (99% pure) in olive oil by gavage 5 days/week for 3 months, after an acclimation period of 1 week. Then, 5 treated males were in each case mated with 5 untreated or treated females and 5 untreated males were in each case mated with 5 untreated or treated females. Treated females were dosed throughout pregnancy but undosed during the lactation period of the offspring; in addition, 2 untreated females, which have been mated with untreated males, were dosed during the lactation period of the offspring. Pups, non-treated, were sacrificed 3 month post-partum (Ciss, 1978; Cisset al.1980b). Mortality, vitality and behaviour of pups from treated and untreated animals were the same. In addition, no histopathological changes in organs occurred among the young animals regardeless on treatment. Therefore, it can be said that at the dose used in this study, 2-nitrotoluene did not induce developmental toxicity. Furthermore, there was no toxicity derived from transfer of the substance through the milk. Within the framework of a reproduction/developmental toxicity screening study performed by Huntingdon, 1994 (cited in KemI 1994), male and female CD rats received 2-nitrotoluene at daily doses of 0, 50, 150 or 450 mg/kg/d by gavage in corn oil over a total period of approximately 10 weeks (2 weeks prior to mating, 2 weeks´ mating period, 20 days´pregnancy and 21 days post-partum). Pups were sacrificed on day 21 post-partum. For the 450 mg/kg/d group wet coats generally occurred for both sexes and brown stained coats were also observed in all males followed by most females. Lower body weight gain and food consumption occurred for males from 150 mg/kg/d. For females lower body weight gain occurred during pregnancy for the 450 mg/kg/d group but recovered Day 21 post partum. Food consumption was lower from 150 mg/kg/d Days 1 to 13 post partum. The parent animals showed increases in liver weight, from 50 mg/kg/d (females) and 150 mg/kg/d (male), and in both kidney and spleen weights (from 150 mg/kg/d in both sexes). In relation to the reproductive system, there was a dosage-related decrease of epididymis, seminal vesicles and prostate weights from 150 mg/kg/d and of testes at 450 mg/kg/d. 3 out of 12 females from the 450 mg/kg/d group died in the immediate post natal period (Day 1 or 2 post-partum), and had dead implantations in the uteri. A dosage-related retardation in pup growth was apparent in all treated groups from the 4thor 8thday post-partum. The mortality of 3 among 12 dams treated with 450 mg/kg/d of 2-nitrotoluene is attributed to systemic toxicity of the test material; consequently, the foetus mortality is seen as a secondary effect of maternal toxicity. The retardation in pup growth could be indicative of developmental toxicity; however, in the absence of further details on its severity we are not sure if this effect could be used for classification or it is only a minor developmental change. In addition, if the retardation in pup growth was considered a toxic effect, it cannot be ruled out that some toxicity was due to the transfer of the substance through the milk.
Applicant's summary and conclusion
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