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EC number: 203-813-0 | CAS number: 110-89-4
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The substance is not expected to significantly accumulate in organisms.
Key value for chemical safety assessment
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of piperidine (CAS 110-89-4) (Q)SAR results were used for aquatic bioaccumulation. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, and for reasons of animal welfare, further experimental studies on aquatic bioaccumulation are not provided.
Assessment
No experimental studies are available for the bioaccumulation assessment of the target substance piperidine (CAS 110-89-4).
According to Regulation (EC) 1907 (2006) Annex IX section 9.3.2 column 2, a study on bioaccumulation does not need to be conducted as the substance has a low potential for bioaccumulation. Piperidine has an experimentally determined log Kow of 0.6 to 0.7 (20 °C, pH 10.2-10.4; BASF AG, 1989; report no. BRU 89.122; see IUCLID Ch. 4.7). Regarding these values, accumulation of the substance in organisms is not to be expected. Therefore, and for reasons of animal welfare, a study on bioaccumulation of piperidine is not provided.
However, in order to assess the bioaccumulation potential of piperidine, the BCF of piperidine was calculated with the BCF baseline model v4.11 (OASIS Catalogic v5.14.1.5). The table below lists the applied (Q)SAR model, the estimated BCF values and basic information on the applicability domain (AD). Detailed information on the model’s results and the AD are given in the endpoint study records of IUCLID Chapter 5.3.1.
In addition to the estimated BCF values for piperidine, a read-across was performed to three structurally similar substances for which xperimental data are available: 1 -methylpiperidine (CAS 626 -67 -5), piperazine (CAS 110 -85 -0), and morpholine (CAS 110 -91 -8). The studies were performed according to (equivalent to) OECD 305C by the Japanese governmental institute NITE. The studies were performed with Cyprio carpio as test species. The test design was flow-through with analytical monitoring. The experimentally determined BCF values are in good agreement with the estimated data for the target substance. The BCF values for all three substances were in a range between 0.3 and 6.3 L/kg.
Based on the available estimated and experimental data, significant accumulation in organisms is not to be expected.
Table: Summary of relevant information on
aquatic bioaccumulation of the target substance piperidine (CAS
110-89-4) predicted with the BCF baseline model v4.11 (OASIS Catalogic
v5.14.1.5).
| CAS | Model | BCF [L/kg] | In AD | Remarks |
| 110-89-4 (Piperidine) | BCF baseline model v4.11 (OASIS Catalogic v5.14.1.5): incl. mitigating factors | 3.4 | yes | The substance is in the AD (100% in parametric, structural and mechanistic domain). |
| 110-89-4 (Piperidine) | BCF baseline model v4.11 (OASIS Catalogic v5.14.1.5): no mitigating factors | 16.9 | yes | The substance is in the AD (100% in parametric, structural and mechanistic domain). |
Table: Summary of experimentally determined BCF values
Chemical name |
1-Methylpiperidine |
Piperazine |
Morpholine |
CAS no. |
626-67-5 |
110-85-0 |
110-91-8 |
OECD 305C, Cyprio carpio |
0.5 – 1.2 at 1 mg/L 2.6 – 6.3 at 0.1 mg/L |
≤ 0.3 at 0.1 mg/L ≤ 3.9 at 0.01 mg/L |
≤ 0.3 – 0.65 at 5 mg/L ≤ 2.8 at 0.5 mg/L |
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