Piperidine

Health surveillance data

Administrative data

Endpoint:

health surveillance data

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Zur Problematik der Entwicklung eines biologischen Expositionstests bei Amin-Belastungen.

Author:

Heberer, H

Year:

1986

Bibliographic source:

Z. Klin. Med. 41, 143-146 (1986)

Reference 2

Reference Type:

publication

Title:

Chromatographic Methods for the Study of Amines from Biological Material

Author:

Blau K.

Year:

1961

Bibliographic source:

Biochem. J. 80: 193-200

Materials and methods

Study type:

health record, other

Endpoint addressed:

basic toxicokinetics

Principles of method if other than guideline:

Qualitative and quantitative determination of ammonia (NH₃) and amines in the urine according to Bittersohl and Heberer (Z.gesamte Hyg. 26 (1980), 258-259 and Heberer H et al., Z.gesamte Hyg. 25 (1979), 737-740). The determination of kreatinine was performed according to the Jaffé-reaction.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Piperidine

EC Number:

203-813-0

EC Name:

Piperidine

Cas Number:

110-89-4

Molecular formula:

C5H11N

IUPAC Name:

piperidine

Method

Type of population:

general

Details on study design:

From 5 probands mean values of 5 urine samples per day collected at a given time over a period of 72 hours are given, respectively.
To assess the influence of diet on the excretion of amines, volunteers were fed with 100 g of pure Glucose per day for 72 hours under a safe exclusion of other foods with otherwise normal body burden.

Results and discussion

Results:

Mean values ± standard deviation of the concentration of piperidine in the urine of apparently healthy probands over a period of 72 hours; values in the brackets are the range; VK = variation coefficient:
Proband 1: 54.1 ± 25.7 µmol/L (10.7 - 94.0), VK 47.5
Proband 2: 55 ± 62.8 µmol/L (4.2 - 215), VK 115
Proband 3: 60.8 ± 32.6 µmol/L (22.7 - 129), VK 53.4
Proband 4: 28.5 ± 30.6 µmol/L (0.4 - 127), VK 107
Proband 5: 96.9 ± 86.6 µmol/L (29.1 - 368), VK 89.5
The content of piperidine in the urine depends crucially on the type and amount of food. Circannual differences in the amine excretion in individual subjects have so far not been demonstrated.
In accordance to Blau 1961 (Biochem.J. 80 (1961), 193-200), after fasting, a complete absence of piperidin exkretion was observed and attributed to the unavailability of lysine as a result of starvation.