Piperidine

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Piperidine: a new neuromodular or a hypogenic substance?

Author:

Giacobini E.

Year:

1976

Bibliographic source:

Adv Biochem Psychopharmacol 15, 17-56 (1976)

Reference 2

Reference Type:

secondary source

Title:

Volatile amines in brain.

Author:

Honegger CG and Honegger R

Year:

1960

Bibliographic source:

Nature, 185, 530-532 (1960), cited in Giacobini 1976: Piperidine. Adv Biochem Psychopharmacol 15, 17-56 (1976)

Reference 3

Reference Type:

secondary source

Title:

Distribution of piperidine in the brain and its possible significance in behaviour.

Author:

Abood LG, Rinaldi F and Eagleton V

Year:

1961

Bibliographic source:

Nature 19, 201-202 (1961) cited in Giacobini 1976: Piperidine. Adv Biochem Psychopharmacol 15, 17-56 (1976)

Reference 4

Reference Type:

secondary source

Title:

Estimation of picomole quantities of piperidine in tissues.

Author:

Seiler N, Schneider NH

Year:

1974

Bibliographic source:

Biomed. Mass. Spectr., 1, 381-385 (1974); cited in Giacobini 1976: Piperidine. Adv Biochem Psychopharmacol 15, 17-56 (1976)

Reference 5

Reference Type:

secondary source

Title:

Piperidine in the cerebellum of the dog.

Author:

Kataoka M, Kasé Y, Miyata, T and Kawahito E

Year:

1970

Bibliographic source:

J. Neurochem., 17, 291-292 (1970) cited in Giacobini 1976: Piperidine. Adv Biochem Psychopharmacol 15, 17-56 (1976)

Reference 6

Reference Type:

secondary source

Title:

Amine content of normal human cerebrospinal fluid.

Author:

Perry TL, Hansen S, Jenkins LC

Year:

1964

Bibliographic source:

J. Neurochem. 11, 49-53 (1964), cited in Giacobini 1976: Piperidine. Adv Biochem Psychopharmacol 15, 17-56 (1976)

Materials and methods

Type of study / information:

Summary and critical analysis of the data of piperidine about metabolism, its cellular localization, and its catabolism in the brain as well as elucidation of its possible role in the function of the nervous system, including recent work of the author's laboratory.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Piperidine

EC Number:

203-813-0

EC Name:

Piperidine

Cas Number:

110-89-4

Molecular formula:

C5H11N

IUPAC Name:

piperidine

Results and discussion

Any other information on results incl. tables

Piperidine is found in muscle, liver, heart, kidney, spleen, testes, small intestine, lung of rats at concentrations ranging from 0.115–0.440 nmol/g tissue. Piperidine is also found in the brain of the rat, mouse, cat, pig and rabbit.

The highest endogenous concentrations are found in the brain: In the whole mouse and rat brain the piperidine concentration ranged from 0.016–3.28 nmol/g tissue depending on the extraction and analysis procedures. The concentration in whole human brain was reported as 1.8 nmol/g tissue. The highest concentrations of piperidine in the brain are found in the cerebellum:

3.92–5.18 nmol/g of tissue for the dog, 3.07–3.17 nmol/g of tissue for the mouse, 0.8 nmol/g of tissue for the cat, and 0.047 nmol/g of tissue for the rat. The concentration in other brain regions varied considerably.