Registration Dossier
Registration Dossier
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EC number: 237-075-6 | CAS number: 13598-65-7
Endpoint summary
Administrative data
Description of key information
There was no evidence of significant irritation when ammonium perrhenate was applied to the skin of six rabbits using a 24-hour occluded patch. Although the study did not follow current OECD test guidelines, the deviations would likely have increased the potential to cause an irritant reaction and thus ammonium perrhenate is considered to be non-irritant to the skin.
In an in vitro eye irritation test using the Isolated Chicken Eye (OECD TG438) there was no indication that ammonium perrhenate was likely to cause severe irritation/corrosion. In a subsequent in vivo assay (OECD TG405) in which the substance was applied to the eyes of three rabbits it caused only transient mild irritation, which was not sufficient to meet the criteria for classification as an eye irritant under EC Regulation 1272/2008.
No data were identified relating to irritation to the respiratory tract. Given the results from the skin and eye irritation studies, ammonium perrhenate is unlikely to cause significant respiratory irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No data were identified in humans relating to skin or eye irritation, and no human or animal data in relation to respiratory irritation were found.
There is no indication that ammonium perrhenate is likely to cause significant irritation to the skin, eyes or respiratory tract. When applied to the abraded skin of six rabbits using a 24 -hour occluded patch it failed to cause significant irritation. An in vitro eye irritation test using the Isolated Chicken Eye (OECD TG438) gave no indication that it was likely to cause a severe irritant/corrosive reaction and a subsequent in vivo assay using three rabbits resulted in only transient mild irritation, not sufficient to meet the criteria for classification as an eye irritant under EC Regulation 1272/2008. Although no data were identified relating to irritation to the respiratory tract, the results from the skin and eye irritation studies indicate that ammonium perrhenate is unlikely to cause significant respiratory irritation.
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
Acceptable in vitro and in vivo assays gave results that failed to meet the criteria for classification for skin or eye irritation under EC Regulation 1272/2008.
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