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EC number: 237-075-6
CAS number: 13598-65-7
Positive control: The Test item was stuck on
the cornea surface after the post-treatment rinse. The cornea surface
was not cleared 240 min after the post-treatment rinse.
The negative control and positive
control results were in line with historical data. This experiment was
considered to be valid.
Table Mean values of the treated eyes
and ICE class*
Mean maximum corneal swelling at up to 75 min
Mean maximum corneal swelling at up to 240 min
Mean maximum corneal opacity
Mean fluorescein retention
Overall ICE Class*
3 x I
* See OECD TG 438.
An in vitro eye irritation
study of the test item Ammonium Perrhenate was performed in isolated
chicken’s eyes. The irritation effects of the test item were evaluated
according to the OECD No.: 438 (07thSeptember 2009).
After the zero reference measurements,
the eye was held in horizontal position and 30 mg of Ammonium Perrhenate
was applied onto the centre of the cornea such that the entire surface
of the cornea was covered. After 10 seconds, the surface was rinsed with
saline. The positive control eyes were treated in a similar way with 30
mg Imidazole. The negative control eye was treated with 30 µL of
In this in vitro eye irritation
study in the Isolated Chicken Eyes model with Ammonium Perrhenate, the
results suggest that the test item was not severly irritating/corrosive.
According to the guideline OECD 438,Ammonium Perrhenate does not require
a classification as a severe eye irritant; an in vivo rabbit
study is required to determine classification for mild/moderate
irritation or non-irritant.
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