Registration Dossier

Classification & Labelling & PBT assessment

GHS

General Information

Name:
Pyrochlore
Implementation:
EU
Type of classification:
self-classification
Remarks:

Pyrochlore:

The overall chemical and physiological properties of pyrochlore are principally characterised by a degree of inertness because of the specific synthetic process (calcination at high temperatures, approximately 1000°C), rendering the substance to be of a unique, stable crystalline structure in which the majority of atoms are tightly bound and not prone to dissolution in environmental and physiological media. This has been shown in in-vitro bioaccessibility testing for antimony, in which dissolved Sb concentrations were below 105 ug/L even at the highest loading of 0.1g/L, thus implying a solubility of < 0.12% of antimony. Hence, Sb can be considered as not bioavailable and is not regarded concerning toxicological and environmental effects.

On the other hand, lead dissolution levels were much higher (up to 6.2 mg/L at pH 1.7) and therefore have to be regarded concerning toxicological and environmental aspects. Substance-specific data on the toxicity of pyrochlore is only partly available, so that read-across to lead oxide and sparingly soluble lead compounds was conducted in order to complete the data set.

It is explicitely noted here that due to the outcome of an acute toxicity study according to OECD 401, classification as Acute Tox. 4; H302 for the pigment pyrochlore is not recommended.

Lead:

Existing classification in accordance with Commission Regulation (EC) No 1272/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures. Index No. 082-001-00-6 "lead compounds with the exception of those specified elsewhere in this Annex". The basis of the original environmental classifications is unknown.  However current industry data supports the EU environmental classifications. The basis of the original human health classifications is unknown.  However the lead oxide CSR includes a self classification section that, based on industry’s analysis of current data, proposes CHANGES TO THE EU CLASSIFICATION. Industry proposes changes to the existing harmonised classification with the addition of Carc. 2 and the change of STOT RE2 to STOT RE1 that are not covered in Annex VI.

As a result, the classification for acute toxicity via the oral route and by inhalation is not supported for the pigment pyrochlore.

Related composition

Related composition:
Composition 3

Classificationopen allclose all

Explosives
Reason for no classification:
data conclusive but not sufficient for classification
Flammable gases and chemically unstable gases
Reason for no classification:
data conclusive but not sufficient for classification
Aerosols
Reason for no classification:
data conclusive but not sufficient for classification
Oxidising gases
Reason for no classification:
data conclusive but not sufficient for classification
Gases under pressure
Reason for no classification:
data conclusive but not sufficient for classification
Flammable liquids
Reason for no classification:
data conclusive but not sufficient for classification
Flammable solids
Reason for no classification:
data conclusive but not sufficient for classification
Self-reactive substances and mixtures
Reason for no classification:
data conclusive but not sufficient for classification
Pyrophoric liquids
Reason for no classification:
data conclusive but not sufficient for classification
Pyrophoric solids
Reason for no classification:
data conclusive but not sufficient for classification
Self-heating substances and mixtures
Reason for no classification:
data conclusive but not sufficient for classification
Substances and mixtures which in contact with water emit flammable gases
Reason for no classification:
data conclusive but not sufficient for classification
Oxidising liquids
Reason for no classification:
data conclusive but not sufficient for classification
Oxidising solids
Reason for no classification:
data conclusive but not sufficient for classification
Organic peroxides
Reason for no classification:
data conclusive but not sufficient for classification
Corrosive to metals
Reason for no classification:
data conclusive but not sufficient for classification
Desensitized explosives
Reason for no classification:
data lacking
Acute toxicity - oral
Reason for no classification:
data conclusive but not sufficient for classification
Acute toxicity - dermal
Reason for no classification:
data conclusive but not sufficient for classification
Acute toxicity - inhalation
Reason for no classification:
data conclusive but not sufficient for classification
Skin corrosion / irritation
Reason for no classification:
data conclusive but not sufficient for classification
Serious eye damage / eye irritation
Reason for no classification:
data conclusive but not sufficient for classification
Respiratory sensitisation
Reason for no classification:
data conclusive but not sufficient for classification
Skin sensitisation
Reason for no classification:
data conclusive but not sufficient for classification
Aspiration hazard
Reason for no classification:
data conclusive but not sufficient for classification
Reproductive toxicity
Hazard category:
Repr. 1A
Hazard statement:
H360: May damage fertility or the unborn child <state specific effect if known > <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
Specific effect:
H360Df- May damage the unborn child. Suspected of damaging fertility.
Effects on or via lactation
Reason for no classification:
data conclusive but not sufficient for classification
Germ cell mutagenicity
Reason for no classification:
data conclusive but not sufficient for classification
Carcinogenicity
Hazard category:
Carc. 2
Hazard statement:
H351: Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routs of exposure cause the hazard>.
Route of exposure:
Oral
1. Specific target organ toxicity - single
Reason for no classification:
data conclusive but not sufficient for classification
1. Specific target organ toxicity - repeated
Hazard category:
STOT Rep. Exp. 1
Hazard statement:
H372: Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
Affected organs:
The central nervous system, kidneys and haematological (blood) systems
1.
Concentration range (%):
>= 0.05
Hazard categories:
STOT Rep. Exp. 2
2.
Concentration range (%):
>= 2.5
Hazard categories:
Repr. 2
3.
Concentration range (%):
>= 0.5
Hazard categories:
STOT Rep. Exp. 1
Hazardous to the aquatic environment (acute / short-term)
Reason for no classification:
data lacking
Hazardous to the aquatic environment (long-term)
Hazard category:
Aquatic Chronic 1
Hazard statement:
H410: Very toxic to aquatic life with long lasting effects.
M-Factor acute:
10
M-Factor chronic:
1
Hazardous to the ozone layer
Reason for no classification:
data conclusive but not sufficient for classification
Additional hazard classes:
Aquatic Acute Category 1
Additional hazard statements:
H400

Labelling

Signal word:
Danger

Hazard pictogram

GHS08: health hazard
GHS09: environment

Hazard statements

H351: Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routs of exposure cause the hazard>.
H410: Very toxic to aquatic life with long lasting effects.
H360: May damage fertility or the unborn child <state specific effect if known > <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
H360Df- May damage the unborn child. Suspected of damaging fertility.
H372: Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
H372: Causes damage to organs through prolonged or repeated exposure.

Notes