Registration Dossier

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vivo

Link to relevant study records
Reference
Endpoint:
in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Guideline:
OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
GLP compliance:
not specified
Type of assay:
micronucleus assay
Species:
mouse
Strain:
ICR
Sex:
male/female
Route of administration:
intraperitoneal
Remarks:
Doses / Concentrations:
100/333/1000 mg/kg
Basis:
other: intraperitoneal in corn oil
Sex:
male/female
Genotoxicity:
negative
Conclusions:
Interpretation of results (migrated information): negative
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Justification for classification or non-classification

The classification for this endpoint is negative