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Registration Dossier
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EC number: 435-740-7 | CAS number: 94317-64-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- EPA OPPTS 870.3100 (90-Day Oral Toxicity in Rodents)
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- other: Crl:CD BR
- Sex:
- male/female
- Route of administration:
- other: oral: diet
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 90 days
- Frequency of treatment:
- daily in diet
- Remarks:
- Doses / Concentrations:
0;200;1000;5000 ppm
Basis:
nominal in diet - No. of animals per sex per dose:
- 15
- Dose descriptor:
- NOAEL
- Effect level:
- 74 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: 90 days
- Dose descriptor:
- LOAEL
- Effect level:
- 17 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: 90 days
- Critical effects observed:
- not specified
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEL
- 17 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
- Quality of whole database:
- In a 90d study according to US EPA for males the NOAEL was 74 mg/kg/d, for females the LOAEL 17 mg/kg/d
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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