Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin

The potential of barium oxide to cause dermal corrosion was assessed by a single topical application of 500 μL of the test substance to the Corrositex® Biobarrier Membrane (Corrositex® assay). The Corrositex® Biobarrier Membrane is a test system consisting of a reconstituted collagen matrix. The assay is based on the time that is required for the test substance to penetrate through the Corrositex® Biobarrier Membrane and produce a change in the Chemical Detection System (CDS). In addition to the test substance a positive and a negative control were assessed. The Corrositex® assay showed the following results: The qualification screen demonstrated that the test substance is able to react with the CDS and produce a visible color change. A timescale category test was carried out to distinguish between weak and strong acids or bases. The test substance was assigned to timescale category 1 (having a high acid/alkaline reserve). In the main test four Corrositex® Biobarrier Membranes were treated with the undiluted test substance. The mean break through time of the test substance, determined in the actual Corrositex® assay, was 17 minutes and 16 seconds.

Eye

No data available.


Effects on skin irritation/corrosion: corrosive

Justification for classification or non-classification

A Corrositex® assay conducted according to OECD Guideline 435 (BASF SE 2015) shows a corrosive potential of barium oxide. Based on the results of the assay, the test substance is classified as be corrosive to the skin, category 1B (H314) according to Regulation (EC) No 1272/2008 (CLP).