Registration Dossier
Registration Dossier
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EC number: 248-471-3 | CAS number: 27458-94-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Low potential for reproductive toxicity.
Effects on developmental toxicity
Description of key information
Low potential for developmental toxicity.
Additional information
Developmental toxicity studies conducted by the oral route on two different types of isononanol (and other higher alcohols) produced consistent results and demonstrated that these materials do not affect reproductive parameters. A slight increase in resorptions was observed in several of the studies, but this only occurred in the highest dose group(s) and in the presence of overt maternal toxicity.
Type 1 isononanol had been tested at 0, 144, 720 and 1440 mg/kg bw / day, type 2 at 0, 130, 650 and 1080 mg/ kg bw/ day.
The NOAEL for the isononanol type 1 was determined to be 720 mg/kg bw/ day for the developmental toxicity effects, the NOAEL for the isononanol type 2 was determined to be 650 mg/kg bw/ day.
Justification for classification or non-classification
No classification for reproductive or developmental toxicity is indicated according to the general classification and labeling requirements for dangerous substances and preparations (Directive 67-548-EEC) or the classification, labeling and packaging (CLP) regulation (EC) No 1272/2008.
.Additional information
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