Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original reference in foreign language and not yet available

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Pathogenesis of acute dimethyl sulfate poisoning (an experimental study)
Author:
Batsura YD, Kasparov AA, Krugilov GG and Molodkina NN
Year:
1980
Bibliographic source:
Gig Tr Prof Zabol; 11: 55-57. Cited in: EU RAR (2002)
Reference Type:
secondary source
Title:
EU Risk Assessment Report Dimethyl Sulphate
Author:
European Chemicals Bureau
Year:
2002
Bibliographic source:
EU RAR, Volume 12. Luxembourg 2002

Materials and methods

Principles of method if other than guideline:
Determination of LC50 level in rats after a 4 hr-inhalative exposure to the test substance
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): dimethyl sulphate
No further data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No additional details

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: air
Details on inhalation exposure:
No additional details
Duration of exposure:
4 h
Concentrations:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
No additional details
Statistics:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
45 mg/m³ air
Exp. duration:
4 h
Mortality:
no data, it is reported that groups of animals were sacrificed immediately following exposure and at intervals thereafter.
Clinical signs:
The exposed rats were dyspnoeic and some had nasal discharge
Body weight:
no data
Gross pathology:
cyanosis of the mucosae, hyperemia of the lung, and hemorrhage in the internal organs.
Other findings:
Histological and electron microscopic examination of lung tissue revealed hemorrhage and coagulated proteins in the alveoli. After a latent period of 5-6 hr, accumulation of edematous fluid in the air spaces developed progressively over 24-48 hr

Any other information on results incl. tables

-

Applicant's summary and conclusion