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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study with limited documentation and with no data on GLP compliance. In the OECD SIDS on 2-Naphthol (2002) a similar reliability was assigned.

Data source

Reference
Reference Type:
publication
Title:
An evaluation of 6 short-term tests for detecting organic chemical carcinogens.
Author:
I. F. Purchase, E. Longstaff, J. Ashby, J. A. Styles, D. Anderson, P. A. Lefevre, and F. R. Westwood
Year:
1978
Bibliographic source:
Br J Cancer. 1978 June; 37(6): 873–903.

Materials and methods

Test guideline
Guideline:
other: according to the method described by Ames (1975)
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
2-naphthol
EC Number:
205-182-7
EC Name:
2-naphthol
Cas Number:
135-19-3
Molecular formula:
C10H8O
IUPAC Name:
2-naphthol
Details on test material:
2-naphthol from Fluka

Method

Species / strain
Species / strain / cell type:
other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538
Metabolic activation:
with
Metabolic activation system:
metabolic activation: rat liver S-9
Test concentrations with justification for top dose:
No data

Results and discussion

Test results
Species / strain:
other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538
Metabolic activation:
with
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Remarks on result:
other: other: metabolic activation: rat liver S-9
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative with metabolic activation

An evaluation of the genetic toxicity of 2-naphthol shows negative results with metabolic activation according to the method described by Ames (1975).