Registration Dossier
Registration Dossier
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EC number: 205-182-7 | CAS number: 135-19-3
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary citation. In the OECD SIDS on 2-Naphthol (2002) a similar reliability was assigned.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Industrial Bio-Test Laboratories, Inc., Data Sheets 26-4/1973.
- Author:
- Industrial Bio-Test Laboratories
- Year:
- 1 973
- Bibliographic source:
- As cited in: The Registry of Toxic Effects of Chemical Substances (RTECS). 2-Naphthol.
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-naphthol
- EC Number:
- 205-182-7
- EC Name:
- 2-naphthol
- Cas Number:
- 135-19-3
- Molecular formula:
- C10H8O
- IUPAC Name:
- 2-naphthol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Exposure period: 28 days
- Frequency of treatment:
- continous
- No. of animals per sex per dose:
- no data
Results and discussion
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 10 080 other: mg/kg bw
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Weight loss or decreased weight gain. Effects on kidney, ureter, and bladder; changes in bladder weight (no further details).
Applicant's summary and conclusion
- Conclusions:
- Weight loss or decreased weight gain and effects on kidney, ureter, and bladder and changes in bladder weight were observed in a sub-acute study by oral route on rats.
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