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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: case report
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented german case report, no data on purity and concentration of test item

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Zur Toxikologie des Dimethylsulfats
Author:
Rossmann H
Year:
1952
Bibliographic source:
Zbl. Arbeitsmed. Arbeitsschutz 2, 72-75
Reference Type:
publication
Title:
Recommendation from the Scientific Commitee on Occupational Exposure Limits for dimethyl sulphate
Author:
SCOEL
Year:
2004
Bibliographic source:
SCOEL/SUM/111 November 2004

Materials and methods

Study type:
other: accidental exposure
Endpoint addressed:
acute toxicity: inhalation
Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Type of population:
occupational
Subjects:
- Number of subjects exposed: 2
- Sex: male
- Age: 40 years old
Ethical approval:
not applicable
Route of exposure:
inhalation
Reason of exposure:
accidental
Exposure assessment:
estimated
Details on exposure:
Accidental exposure to DMS of two male employees during cleaning and repairing of DMS filling station without wearing respiratory mask.
Temperature: 4 °C
Exposure duration: 3 hours
Examinations:
Necropsy after fatal death of one employee
Medical treatment:
Yes. Strophanthin was administered to support the employee's heart.

Results and discussion

Clinical signs:
First employee:
Irritation of mucous membrane of the respiratory tract development of lung oedema.
Death after 3 days

Second employee:
cough, irritation of mucous membrane of the respiratory tract, conjunctivitis and ceratitis.
Employee survived.
Results of examinations:
First employee:
Gross pathology: oedema in brain, corrosion of pharynx, larynx and trachea
Histopathology: verified oedema in brain and lung
Effectivity of medical treatment:
not effective: one patient died 3 days after accidental exposure
Outcome of incidence:
no data

Applicant's summary and conclusion

Conclusions:
DMS is acute toxic.
Executive summary:

One of two men died after exposure to DMS-vapour for three hours at 4°C without protective clothing (Rossmann 1952). In the person that died, symptoms of intoxication appeared after several hours and consisted of irritation of the upper-respiratory tract and fever. In the hospital he developed irritation of the conjunctivae and glottis oedema. He finally died after 3 days. Autopsy revealed oedema of the lung and brain. Histopathological examination confirmed the pulmonary oedema and showed corrosion of the respiratory tract. The other person reported nasal secretion, dyspnoea, and conjunctivitis of both eyes. The second day of hospitalisation, he also developed fever, after which his general condition improved and with only minor lung problems he was released from hospital on day eight.