Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-039-3 | CAS number: 102-54-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a peer reviewed study performed to OECD Guideline 401, ferrocene has an oral LD50 1320mg/kg bw (Bingham, 2001).
In a study performed to OECD Guideline 402, ferrocene has a dermal LD50 >3000mg/kg bw (Innospec 1987).
Acute Inhalation studies have been waived based on existing data, exposure considerations and animal welfare.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 320 mg/kg bw
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In a peer reviewed study performed to OECD Guideline 401, ferrocene has an oral LD50 of 1320mg/kg bw
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 320 mg/kg bw
- Quality of whole database:
- Good peer reviewed study (Klimisch score 2)
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Type of coverage:
- occlusive
- Vehicle:
- other: material wetted
- Duration of exposure:
- 24hours
- Doses:
- 3000 mg/ kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 3 000 mg/kg bw
- Mortality:
- There was no deaths at this dosage
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a study performed to OECD guideline 402, Ferrocene had a dermal LD50>3000mg/kg bw and is not classified by this exposure route
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 000 mg/kg bw
- Quality of whole database:
- Good peer reviewed study (Klimisch score 1)
Additional information
In a study performed to OECD guideline 401, Ferrocene had an LD50 1320mg/kg bw and is classified as harmful by oral exposure
In a study performed to OECD guideline 402, Ferrocene had an NOEC 3000mg/kg bw and is not classified by dermal exposure
Acute Inhalation studies have been waived based on existing data, exposure considerations and animal welfare
Justification for selection of
acute toxicity – oral endpoint
Only study available
Justification for selection of acute toxicity – inhalation endpoint
No acute inhalation study is available
Ferrocene is a non-volatile solid and exposure to the material is low
during manufacture.
Once manufactured the vast majority of the material is sold as cushions
and pellets so exposure to the downstream user is also very low.
Data is available for oral and dermal routes and in the interest of
animal welfare this study is waived
Justification for selection of acute toxicity – dermal endpoint
Only one study available
Justification for classification or non-classification
In a study performed to OECD guideline 401, Ferrocene had an LD50 1320mg/kg bw and is classified as Xn;R20 harmful if swallowed (DPD), and acute toxicity category 4; harmful if swallowed (CLP)
In a study performed to OECD guideline 402, Ferrocene had an LD50>3000mg/kg bw and is not classified by dermal exposure
Acute Inhalation studies have been waived based on existing data, exposure considerations and animal welfare. However as the material is harmful by repeat exposure it is advisable to classify as harmful by inhalation for acute exposure too. Therefore it is classified as Xn;R22 harmful if inhaled (DPD), and acute toxicity category 4; harmful by inhalation (CLP)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.