Dimethyl phosphonate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1962

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given. Adopted from OECD SIDS. The original source is available and has been reviewed.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1992

Report date:

1992

Reference 2

Reference Type:

secondary source

Title:

Dimethyl phosphonate - CAS No: 868-85-9 - SIDS Initial Assessment Report.

Author:

OECD

Year:

2004

Bibliographic source:

UNEP Publications

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Ten male rats were exposed to 7100 mg/m³ dimethyl phophonate (calculate exposure concentration from air flow and net loss of material) for 6 hours.

GLP compliance:

no

Remarks:

GLP was not mandatory at the time of the study

Test type:

other: no data

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Dimethyl phosphonate

EC Number:

212-783-8

EC Name:

Dimethyl phosphonate

Cas Number:

868-85-9

Molecular formula:

C2H7O3P

IUPAC Name:

dimethyl phosphonate

Details on test material:

- Name of test material (as cited in study report): dimethyl phosphonate
- Substance type: technical product
- Assumed purity: 100%

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
-Housing: at termination of the exposure the animals were housed by species in metal cages elevated above the droppings.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: no data

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
-Animals were exposed for 6 hours to the near saturated vapours of the test materials. Each exposure was conducted in a 500-liter stainless steel inhalation chamber equipped at the inlet with one or two fritted-disc glass bubblers which contained the test material. A glass trap was placed in the line between this vapour generator and the chamber to collect any entrained liquid. The air flow through the system was 18 liters per minutes (one bubbler), or 35 liters per minute (two bubblers). Dimethyl phosphonate vapour was generated at room temperature.
No attempt was made to determine the actual chamber concentration during the exposure. The mean theoretical concentration was calculated for each material from the air flow and net loss material.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

6 h

Concentrations:

7100 mg/m³.

No. of animals per sex per dose:

10 (male rats).

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days.
- Other examinations performed: mortality, toxic effects, autopsy.

Statistics:

Not performed

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LC50

Effect level:

> 7 100 mg/m³ air (nominal)

Based on:

test mat.

Exp. duration:

6 h

Mortality:

no deaths

Clinical signs:

other: no clinical signs

Body weight:

No data

Gross pathology:

Congestion and hemorrhage in the lungs.

Other findings:

No further data

Any other information on results incl. tables

Based on the study results, the test substance is not to be classified.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Executive summary:

Ten male rats were exposed to 7100 mg/m³ dimethyl phosphonate (calculated exposure concentration from air flow and net loss of material) for 6 hours. No deaths occurred. Congestion and hemorrhage in the lungs were observed in rats. Based on the study results, the test substance is not to be classified.