Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
water solubility
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Justification for type of information:
QSAR prediction - not commonly used calculation method in the time of the calculation.
Principles of method if other than guideline:
method not given
GLP compliance:
no
Water solubility:
586 mg/L
Temp.:
25 °C
Remarks on result:
other: pH value not given

result: log(1/S)=2.40; S=molar water solubility (mol/l)
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Principles of method if other than guideline:
not specified
Water solubility:
< 1 g/L
Temp.:
19.5 °C
Remarks on result:
other: The pH-value is not reported.
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Principles of method if other than guideline:
not specified
GLP compliance:
not specified
Water solubility:
ca. 0.6 g/L
pH:
ca. 3.8
Remarks on result:
other: The temperature was not reported.
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
method not specified
GLP compliance:
not specified
Water solubility:
36 mg/L
Temp.:
25 °C
Remarks on result:
other: The pH-value is not reported.
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study according to Japanese national guideline. Original report in Japanese.
Principles of method if other than guideline:
Method: Japanese national guideline (1988)
GLP compliance:
not specified
Water solubility:
370 mg/L
Temp.:
25 °C
Remarks on result:
other: The pH-value is not reported.
Endpoint:
water solubility
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
WSKOW v. 1.41
Principles of method if other than guideline:
Calculated with (WSKOW v. 1.41)
GLP compliance:
no
Water solubility:
216 mg/L
Temp.:
25 °C
Remarks on result:
other: pH not reported

The EPIWIN Program (EPA, 2004) used for calculation also cites a water solubility of 360 mg/l in the SRC PhysProp Database as experimental data of Yalkowsky and Dannenfelser (1992)
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
method not specified
GLP compliance:
not specified
Key result
Water solubility:
360 mg/L
Remarks on result:
other: The pH-value and the temperature were not reported. The value is assumed to be measured at 25 °C

The pH-value and the temperature were not reported. The value is assumed to be measured at 25 °C

Executive summary:

HSDB, 2009

Aqueous solubility of phthalimide: 360 mg/l.

The temperature is not reported. The value is assumed to be measured at 25 °C.

Description of key information

Available sources give consistent values between 200 and 600 mg/L. 

Key value for chemical safety assessment

Water solubility:
360 mg/L
at the temperature of:
25 °C

Additional information

Although a certain discrepancy is observed in the values from different sources, the available data is sufficient to decide on a value to be considered as key. 


One aberrrant value is possibly explained by inaccurate reporting.