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EC number: 221-374-3 | CAS number: 3081-01-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In conclusion, the test substance 7PPD showed a practically non-irritating potential to rabbit skin (Monsanto Co. 1973). The even very low skin irritation potential is confirmed by another skin irritation study (Monsanto Co. 1967a). A rather slight and transient eye irritation potential is noted in an eye irritation study (Monsanto Co. 1973). This finding is supported by an earlier eye irritating study, which revealed mild and transient eye irritating effects of 7PPD (Monsanto Co. 1967a).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
- Principles of method if other than guideline:
- other: skin irritation study
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: intact and abraded skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 7 days
- Number of animals:
- 6
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: 48 h were not evaluated; at 24 h and 72 h no skin irritation observed
- Remarks on result:
- other: slight defatting effect
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: 48 h were not evaluated; at 24 h and 72 h, no details on erythema score given, however, no skin irritation observed
- Remarks on result:
- other: slight defatting effect
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: 48 h were not evaluated; at 24 h and 72 h no details on edema score given, however, no skin irritation observed
- Remarks on result:
- other: slight defatting effect
- Interpretation of results:
- not irritating
Reference
slight defatting effect, skin flaked off in seven to ten days. No injury in deph.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
- Principles of method if other than guideline:
- other: eye irritation study in vivo
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 7 d
- Number of animals or in vitro replicates:
- 6
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 3.5
- Max. score:
- 110
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: slightly erythema, discharge
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 6.6
- Max. score:
- 110
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: slight erythema, moderate to copious discharge
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 3.6
- Max. score:
- 110
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: slight erythema, slight discharge
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks:
- no details on chemosis reported
- Remarks on result:
- other: no details on chemosis reported
- Remarks:
- .
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks:
- no details on cornea opacity reported
- Remarks on result:
- other: no details on cornea opacity reported
- Remarks:
- .
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks:
- no details on iris score reported.
- Remarks on result:
- other: no details on iris score reported.
- Remarks:
- .
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks:
- no details on conjunctivae score reported.
- Remarks on result:
- other: no details on conjunctivae score reported.
- Remarks:
- .
- Interpretation of results:
- not irritating
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
- Principles of method if other than guideline:
- other: in vivo eye irritation study
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: albino
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 7 d
- Number of animals or in vitro replicates:
- 3
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 24.3
- Max. score:
- 110
- Reversibility:
- fully reversible within: 168 h
- Remarks on result:
- other: mild redness, slight edema, copious discharge, slight cloudiness
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 19.3
- Max. score:
- 110
- Reversibility:
- fully reversible within: 168 h
- Remarks on result:
- other: discharge ceased within 48 h
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 13
- Max. score:
- 110
- Reversibility:
- fully reversible within: 168 h
- Remarks on result:
- other: discharge ceased within 48 h
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 7
- Max. score:
- 110
- Reversibility:
- fully reversible within: 168 h
- Remarks on result:
- other: cornea clarity was normal in less than five days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 120 h
- Score:
- 2.6
- Max. score:
- 110
- Reversibility:
- fully reversible within: 168 h
- Remarks on result:
- other: cornea clarity was normal in less than five days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 168 h
- Score:
- 0
- Max. score:
- 110
- Reversibility:
- fully reversible
- Remarks on result:
- other: no effects documented
Referenceopen allclose all
Immediate after application: slight discomfort
1 hour after application: slight erythema, very slight edema, copious discharge
The authors classed the test compound as a mild irritant in male and female rabbits. The average maximum score was 24.3 out of a possible 110 in one hour.
Little discomfort was shown immediatly following application.
mild redness, slight edema, copious discharge and slight cloudiness was recorded the first hour. Inflammation reduced somewhat overnight. discharge ceased within 48 -hours. corneal clarity was normal in less than five days with only a trace of erythema still present.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin
The skin irritation potential of the test substance 7PPD was evaluated in a skin irritation study with six New Zealand Albino rabbits (Monsanto Co.1973). The undiluted test substance (0.5 mL) was applied under semi-occlusive dressings to clipped intact and abraded skin of 6 New Zealand albino rabbits for 24 hours. A 7-day observation period followed the test substance application. The test substance 7PPD was practically non-irritating to rabbit skin (mean irritation score intact and abraded skin: 0). However, a slight defatting effect (skin flaked off in seven to ten days) were observed. In an earlier skin irritation study transient and mild skin irritating effects were noted in treated rabbits (maximum score 2.3/8 at 24 h). The effects were fully reversible within 120 hours after treatment (Monsanto Co. 1967).
Eye
The eye irritating potential of the test substance 7PPD was evaluated in an eye irritation study with six New Zealand albino rabbits (Monsanto Co 1973). The undiluted test substance (0.1 mL) was placed into eyes of six rabbits. A 7-day observation period followed the application of the test substance. Eye response were scored in accordance with the Federal Hazardous substances Act (F. H. S. A.), 21 CFR, § 191.12 (1964). The test substance was slightly irritating to the rabbit eye (irritation score 24, 48, and 72 hours: 3.5/110.0). Effects on the conjunctivae were noted in all animals at 24 and 48 hours (mean score 24 h: 6.6/110, 48 h: 3.6) but were reversible within 72 hours. The test substance was not classified as eye irritating. In an earlier eye irritation study with rabbits, the test substance was classified as mild irritant with an average maximum irritation score of 24.3/110 one hour after treatment and average irritation scores of 19.3, 13.0, 7.0 and 2.6 at 24, 48, 72 and 120 hours, respectively. The effect was fully reversible after 168 hours (Monsanto Co. 1967).
Justification for classification or non-classification
No classification is required according to the classification criteria 67/548/EWG and regulation no. 1272/2008 (GHS).
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