Registration Dossier
Registration Dossier
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EC number: 221-374-3 | CAS number: 3081-01-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- other: acute dermal toxicity study
- GLP compliance:
- no
- Test type:
- other: acute dermal toxicity study
Test material
- Reference substance name:
- N-(1,4-dimethylpentyl)-N'-phenylbenzene-1,4-diamine
- EC Number:
- 221-374-3
- EC Name:
- N-(1,4-dimethylpentyl)-N'-phenylbenzene-1,4-diamine
- Cas Number:
- 3081-01-4
- Molecular formula:
- C19H26N2
- IUPAC Name:
- N1-(5-methylhexan-2-yl)-N4-phenylbenzene-1,4-diamine
- Details on test material:
- Santoflex 14
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 5010, 7940 mg/kg
- No. of animals per sex per dose:
- 1 to 2 per dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 010
- Remarks on result:
- other: Clinical signs: reduced appetite and activity (survivors), increasing weakness, collapse and death (decents); gross autopsy:hemorrhagic areas of the lung, liver, spleen, and kidney discoloration, gastrointestinal inflammation (decents)
Any other information on results incl. tables
Mortality:
time of mortality: 8 days
5010 mg/kg: 0/1 male
7940 mg/kg: 1/1 male, 0/1 female, combinded: 1/2
Signs of intoxication: reduced appetite and activity (four to seven days in survivors), increasing weakness, collapse and death (decent)
Gross autopsy:
Decent: hemorrhagic areas of the lung, liver, spleen, and kidney discoloration, gastrointestinal inflammation
Survivors (14 days): Viscera appeared normal
Applicant's summary and conclusion
- Executive summary:
LD50 rabbit: >5010 mg/kg
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