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Diss Factsheets
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EC number: 221-374-3 | CAS number: 3081-01-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles
- Guideline:
- other:
- Principles of method if other than guideline:
- Shake Flask Carbon Dioxide Evolution Procedure:
American Society for Testing Materials, Proposed Standard Practice for the Determination of the Ultimate Biodegradability of Organic Chemicals,
Draft No. 3, ASTM E35.24 Subcommittee, Aquatic Biotransformation Task Group, 2/80. - GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: soil, raw sewage, and activated sludge non adapted
- Duration of test (contact time):
- 35 d
- Initial conc.:
- 20 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 35 d
- Results with reference substance:
- Positive Control: in the range of 75 - 95%
- Validity criteria fulfilled:
- yes
- Remarks:
- Carbon dioxide evolution for the positive control was in the expected 70-95 percent range.
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- N-(1,4-dimethylpentyl)-N'-phenylbenzene-1,4-diamine showed 0 % degradation after 35 days, (Monsanto, 1981).
- Executive summary:
In a test conducted according to the American Society for Testing Materials, Proposed Standard Practice for the Determination of the Ultimate Biodegradability of Organic Chemicals, Draft No. 3, ASTM E35.24 Subcommittee, Aquatic Biotransformation Task Group, 2/80, N-(1,4-dimethylpentyl)-N'-phenylbenzene-1,4-diamine (7PPD) showed 0 % degradation after 35 days.
The result of this study indicates that 7PPD (Santoflex 14) may persist as either the parent compund or slightly altered intermediates in a natural aquatic environment, (Monsanto, 1981).
Reference
Description of key information
A study designated as the Key Study for 7PPD indicates that the substance is not readily biodegradable with 0 % biodegradation after 35 days.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Additional tests are available for 6PPD. Due to the analogous structure to 6PPD (the difference is an additional methyl group in 7PPD) the study from the supporting substance was used to read across. Both substances have similar physico-chemical properties. They hydrolyse rapidly and have a common hydrolysis product. The test conducted according to the OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)) showed a 2 % degradation for 6PPD after 4 weeks, and the following degradation products were detected: Phenylbenzoquinone imine and 1,3-dimethylbutylamine. Further degradation products were stated: p-benzoquinone, 4-hydroxydiphenylamine, aniline.
As 7PPD is known to hydrolyze rapidly (half-life 7 h), the occurrence of the respective amine of 7PPD (1,4-dimethylpentylamine) would be expected also in biodegradation tests. As such amines are readily biodegradable, this would normally be reflected in a higher biodegradation rate. According to stoichiometric relations a biodegradation of about 40 % could theoretically be achieved. The data from different sources however clearly show, this is not the case. A possible explanation of this fact that ready biodegradation tests are performed typically in concentrations of 100 mg/L which is far above the solubility of 7PPD in water (0.7 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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