Registration Dossier

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was performed pre-GLP and pre-guideline. Nevertheless it gives a good indication of dermal absorption for this substance.

Data source

Reference
Reference Type:
publication
Title:
Absorption of some organic compounds through the skin in man
Author:
Feldmann, R.J., Maibach, H.I.
Year:
1970
Bibliographic source:
J Invest Dermatol (54)5 399-404

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
see materials and methods
GLP compliance:
no
Remarks:
pre-GLP

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Potassium thiocyanate, no further information.
Radiolabelling:
yes
Remarks:
14C

Test animals

Species:
human

Administration / exposure

Type of coverage:
open
Vehicle:
acetone
Duration of exposure:
24 hours
Doses:
4 µg/cm2 on a 13 cm2 area
No. of animals per group:
6
Control animals:
no

Results and discussion

Percutaneous absorption
Dose:
4 µg/cm2
Parameter:
percentage
Absorption:
10.15 %
Remarks on result:
other: 24 h
Remarks:
SD 6.60%

Any other information on results incl. tables

See attached table.

Applicant's summary and conclusion

Executive summary:

The authors studied the percutaneous penetration of 21 organic chemicals. The experimental method consisted of the application of the chemical to the human forearm and quantitating its penetration through the skin by its appearance in urine. The recovery from after urine was 10.15% ± 6.60% of the administered dose for potassium thiocyanate, 4 µg/cm2 on a 13 cm2 area, after a collection period of 120 hours.