Registration Dossier
Registration Dossier
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EC number: 217-175-6 | CAS number: 1762-95-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary table with LD50 values from literature.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Author:
- RTECS
- Year:
- 1 909
- Bibliographic source:
- Journal of Pharmacology and Experimental Therapeutics (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
- Reference Type:
- publication
- Title:
- No information
- Author:
- RTECS
- Year:
- 1 951
- Bibliographic source:
- Japanese Journal of Pharmacology (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951
- Reference Type:
- publication
- Title:
- No information
- Author:
- RTECS
- Year:
- 1 940
- Bibliographic source:
- Journal of the American Pharmaceutical Association, Scientific Edition (Washington, DC) V.29-49, 1940-60
- Reference Type:
- publication
- Title:
- No information
- Author:
- RTECS
- Year:
- 1 925
- Bibliographic source:
- Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie (Berlin, Ger.) V.110-253, 1925-66.
Materials and methods
Test material
- Reference substance name:
- Sodium thiocyanate
- EC Number:
- 208-754-4
- EC Name:
- Sodium thiocyanate
- Cas Number:
- 540-72-7
- IUPAC Name:
- sodium thiocyanate
Constituent 1
Results and discussion
Any other information on results incl. tables
Route |
Organism |
Dose |
Reference |
intraperitoneal |
rat |
LD50 540 mg/kg |
Journal of Pharmacology and Experimental Therapeutics (Williams & Wilkins Co., , , ) V.1- 1909/10- |
intraperitoneal |
mouse |
LD50 500 mg/kg |
Japanese Journal of Pharmacology (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, , Sakyo-ku, Kyoto 606, Japan) V.1- 1951 |
subcutaneous |
mouse |
LDLo 400 mg/kg |
Journal of the American Pharmaceutical Association, Scientific Edition (, ) V.29-49, 1940-60. |
intravenous |
mouse |
LD50 484 mg/kg |
Journal of the American Pharmaceutical Association, Scientific Edition (, ) V.29-49, 1940-60. |
intravenous |
dog |
LDLo 100 mg/kg |
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie (, ) V.110-253, 1925-66. |
subcutaneous |
rabbit |
LDLo 200 mg/kg |
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie (, ) V.110-253, 1925-66. |
intravenous |
rabbit |
LDLo 100 mg/kg |
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie (, ) V.110-253, 1925-66. |
Intraperitoneal |
guinea pig |
LDLo 500 mg/kg |
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie (, ) V.110-253, 1925-66. |
Subcutaneous |
guinea pig |
LDLo 500 mg/kg |
Journal of the American Pharmaceutical Association, Scientific Edition (, ) V.29-49, 1940-60. |
Applicant's summary and conclusion
- Conclusions:
- The reported acute toxicity via other routes for sodium thiocyanate in RTECS shows an LD50 via i.p. of 500 in mice, 540 in rat, and 500 mg/kg in guinea pig. Further LDlo values reported involving subcutaneous and intravenous dosing in various species range between 100 and 484 mg/kg.
- Executive summary:
Summary table with acute toxicity values via other routes from RTECS for sodium thiocyanate.
Route
Organism
Dose
Reference
intraperitoneal
rat
LD50 540 mg/kg
Journal of Pharmacology and Experimental Therapeutics (Williams & Wilkins Co., , , ) V.1- 1909/10 -
intraperitoneal
mouse
LD50 500 mg/kg
Japanese Journal of Pharmacology (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, , Sakyo-ku, Kyoto 606, Japan) V.1- 1951
subcutaneous
mouse
LDLo 400 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition (, ) V.29-49, 1940-60.
intravenous
mouse
LD50 484 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition (, ) V.29-49, 1940-60.
intravenous
dog
LDLo 100 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie (, ) V.110-253, 1925-66.
subcutaneous
rabbit
LDLo 200 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie (, ) V.110-253, 1925-66.
intravenous
rabbit
LDLo 100 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie (, ) V.110-253, 1925-66.
Intraperitoneal
guinea pig
LDLo 500 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie (, ) V.110-253, 1925-66.
Subcutaneous
guinea pig
LDLo 500 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition (, ) V.29-49, 1940-60.
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