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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Summary table with LD50 values from literature.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
No information
Author:
RTECS
Year:
1909
Bibliographic source:
Journal of Pharmacology and Experimental Therapeutics (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Reference Type:
publication
Title:
No information
Author:
RTECS
Year:
1951
Bibliographic source:
Japanese Journal of Pharmacology (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951
Reference Type:
publication
Title:
No information
Author:
RTECS
Year:
1940
Bibliographic source:
Journal of the American Pharmaceutical Association, Scientific Edition (Washington, DC) V.29-49, 1940-60
Reference Type:
publication
Title:
No information
Author:
RTECS
Year:
1925
Bibliographic source:
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie (Berlin, Ger.) V.110-253, 1925-66.

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Route  

Organism

Dose  

Reference

intraperitoneal  

rat

LD50 540 mg/kg   

Journal of Pharmacology and Experimental Therapeutics   (Williams & Wilkins Co., , , )  V.1-    1909/10-

intraperitoneal

mouse

LD50 500 mg/kg    

Japanese Journal of Pharmacology   (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, , Sakyo-ku, Kyoto 606, Japan)  V.1-    1951

subcutaneous

mouse

LDLo 400 mg/kg   

Journal of the American Pharmaceutical Association, Scientific Edition (, ) V.29-49, 1940-60.

intravenous  

mouse 

LD50 484 mg/kg   

Journal of the American Pharmaceutical Association, Scientific Edition (, ) V.29-49, 1940-60.

intravenous

dog

LDLo 100 mg/kg

Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie   (, ) V.110-253, 1925-66. 

subcutaneous

rabbit

LDLo 200 mg/kg

Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie   (, ) V.110-253, 1925-66. 

intravenous

rabbit

LDLo 100 mg/kg

Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie   (, ) V.110-253, 1925-66. 

Intraperitoneal

guinea pig

LDLo 500 mg/kg

Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie   (, ) V.110-253, 1925-66. 

Subcutaneous

guinea pig

LDLo 500 mg/kg

Journal of the American Pharmaceutical  Association, Scientific Edition (, ) V.29-49, 1940-60.

Applicant's summary and conclusion

Conclusions:
The reported acute toxicity via other routes for sodium thiocyanate in RTECS shows an LD50 via i.p. of 500 in mice, 540 in rat, and 500 mg/kg in guinea pig. Further LDlo values reported involving subcutaneous and intravenous dosing in various species range between 100 and 484 mg/kg.
Executive summary:

Summary table with acute toxicity values via other routes from RTECS for sodium thiocyanate.

 

Route

Organism

Dose

Reference

intraperitoneal

rat

LD50 540 mg/kg

Journal of Pharmacology and Experimental Therapeutics (Williams & Wilkins Co., , , ) V.1- 1909/10 -

intraperitoneal

mouse

LD50 500 mg/kg

Japanese Journal of Pharmacology (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, , Sakyo-ku, Kyoto 606, Japan) V.1- 1951

subcutaneous

mouse

LDLo 400 mg/kg

Journal of the American Pharmaceutical Association, Scientific Edition (, ) V.29-49, 1940-60.

intravenous

mouse

LD50 484 mg/kg

Journal of the American Pharmaceutical Association, Scientific Edition (, ) V.29-49, 1940-60.

intravenous

dog

LDLo 100 mg/kg

Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie (, ) V.110-253, 1925-66.

subcutaneous

rabbit

LDLo 200 mg/kg

Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie (, ) V.110-253, 1925-66.

intravenous

rabbit

LDLo 100 mg/kg

Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie (, ) V.110-253, 1925-66.

Intraperitoneal

guinea pig

LDLo 500 mg/kg

Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie (, ) V.110-253, 1925-66.

Subcutaneous

guinea pig

LDLo 500 mg/kg

Journal of the American Pharmaceutical Association, Scientific Edition (, ) V.29-49, 1940-60.