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Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
IN FRENCH. The study would be given Klimisch 3 from an OECD 414 perspective. It supports the knowledge on the effects that thiocyanates have on the thyroid gland. The study is not performed according to standard protocol or GLP and it has many deviations. The major ones are: No dose response can be derived (single dose), the number of animals is too limited, the exposure period does not meet the guideline.

Data source

Reference
Reference Type:
publication
Title:
Induction and reversibility of thyroid proliferative changes in suckling rats given thiocyanate (IN FRENCH)
Author:
Soussia , L., F. Ben Hamida, F., Guermazi, F., Zeghal, N.
Year:
2004
Bibliographic source:
Ann. Endocrinol., 2004 ; 65, 5 : 451-458

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Results (fetuses)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion

Executive summary:

Potassium thiocyanate given in the drinking water of pregnant rats led to decreased body weight in their 14-day-old offspring (–27%) without altering thyroid weight. Reduction of the suckling rat’s body weight could be explained be defective thyroxinemia (–38). Plasma FT3 and TSH were unchanged after thiocyanate treatment.

The biochemical changes were in agreement with the histological aspects of the hypothyroid animals. The typical pattern was hyperplastic goiter. Colloid volume was reduced compared with controls. Presence of resorbed peripheral vacuoles, a sign of thyroid hyperactivity, was disclosed by a three-fold increase in radioiodide (131I) uptake compared with controls. When the antithyroid drug was removed from the mother’s milk, the pups’weight increased but did not reach control values. Plasma thyroid hormone levels returned to normal and even exceeded control values in spite of partial recovery of thyroid iodine content when thiocyanate treatment was stopped for ten days.