Registration Dossier

Administrative data

Description of key information

Oral (Rat-Wistar, non-GLP): LD50 = 1760 mg/kg
[Bayer AG, Report dated 1983-06-30]
Inhalative (Rat-Wistar, non-GLP): LC50 > 23 mg/m³
[Bayer AG, Report No. 11752, 1983-04-27]

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
1 760 mg/kg bw

Additional information

The acute oral as well as the acute inhalation toxicity of methyl 3 -aminocrotonate was studied in male and female rats.

The acute oral LD50 was determined to be 1760 mg/kg.

The acute 4 h-LC50 was determined to be > 23 mg/m3, the maximal technically feasible dust concentration at which no mortality and no symptoms occurred.

Justification for classification or non-classification

Based on the study results methyl 3 -aminocrotonate has to be classified according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) as harmfull if swallowed (Xn, R22) or as acute oral toxic, category 4 (H302), respectively.