Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

Methyl 3 -aminocrotonate was shown to be not mutagenic with and without metabolic activation in a bacterial reverse mutation assay with the S. typhimurium strains TA 1535, TA 100, TA 1537 and TA 98. The study was conducted with substance concentrations from 375 to 12000 µg per plate.

Short description of key information:
Gene mutation in vitro (bacterial reverse mutation assay, non-GLP): negative in all tested Salmonella typhimurium strains
[Bayer AG, Report No. 14189, 1986-01-07]

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.