Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report Date:
1983

Materials and methods

Principles of method if other than guideline:
Method according to Kimmerle, G.; Eben, A.: Arch. Toxicology 30, 115, 1973
One group of 10 male and female rats was subjected to a single 4-hour head-nose exposure at a technically maximal feasible dust concentration and observed for mortality, body weights, clinical signs and gross pathological changes through day 14.
GLP compliance:
no
Test type:
other: acute inhalation toxicity, rat
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
3-Aminocrotonsäuremethylester, dust, content not certified

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
nose/head only
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
nominal: 20 mg/m3
analytical: 23 mg/m3
No. of animals per sex per dose:
10
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 23 mg/m³ air (analytical)
Based on:
test mat.
Exp. duration:
4 h

Any other information on results incl. tables

No mortality and no clinical signs occurred, growth was unaffected.

Necropsy at day 14 revealed no test substance-induced abnormalities.

Applicant's summary and conclusion

Executive summary:

The acute inhalation toxicity of methyl 3 -aminocrotonate was determined in male and female rats via single 4-hour head-nose exposure with a technically maximal feasible dust concentration of 23 mg/m3 and a 14 days observation period.

No mortality and clinical signs occurred and therefore, the acute inhalation toxicity was > 23 mg/m3.