Registration Dossier
Registration Dossier
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EC number: 239-816-9 | CAS number: 15721-78-5
Endpoint summary
Administrative data
Description of key information
Additional information
Acute toxicity to fish:
In an study conducted in accordance with OECD 203, the 96- hour acute toxicity study to freshwater fish (Oncorhynchus mykiss), conducted according to GLP, the NOEC of Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is 100% v/v saturated solution (tested at the limit of water solubility. Water solubility is <0.1 mg/l based uponIntertek, 2012(Harlan Laboratories, 2013).
Chronic toxicity to fish
Upon review of the Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine acute ecotoxicity data, the NOEC results to aquatic invertebrates and fish (100% v/v saturated solution) showed no evidence of toxicity reported at the limit of solubility (water solubility is <0.1 mg/l). According to Column 2 of Annex IX of the European Union (EU) Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) 1907/2006 regulation the choice of appropriate testing depends upon the results of the chemical safety assessment. Based on acute aquatic results for Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine, and the low water solubility, toxicity is not expected in chronic toxicity testing, therefore, chronic testing of fish is being waived.
Acute toxicity to aquatic invertebrates:
In a study conducted according to OECD 202, the 48-hour acute toxicity to aquatic invertebrates,Daphina magna, conducted according to GLP, the NOEC of Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is 100% v/v saturated solution (tested at the limit of water solubility). The Water solubility is <0.1 mg/l based uponIntertek, 2012) (Harlan Laboratories, 2013).
Chronic toxicity to aquatic invertebrates:
Upon review of the Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine acute ecotoxicity data, the NOEC results to aquatic invertebrates and fish (100% v/v saturated solution) showed no evidence of toxicity reported at the limit of solubility (water solubility is <0.1 mg/l). According to Column 2 of Annex IX of the European Union (EU) Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) 1907/2006 regulation the choice of appropriate testing depends upon the results of the chemical safety assessment. Based on acute aquatic results for Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine, and the low water solubility, toxicity is not expected in chronic toxicity testing, therefore, chronic testing of invertebrates is waived.
Acute toxicity to algae:
In an OECD 201, 72- hour toxicity to algae (Pseudokirchnerella subcapitata), conducted according to GLP, the NOEC of bis(4-(1,1,3,3-tetramethylbutyl) phenyl) amine is100% v/v saturated solution (tested at the limit of water solubility) (Harlan Laboratories, 2013).
Acute toxicity to microorganisms:
In an OECD 209, 3- hour toxicity to sewage microorganisms, conducted according to GLP, the NOEC of bis(4-(1,1,3,3-tetramethylbutyl) phenyl) amine is100% v/v saturated solution (tested at the limit of water solubility) (Harlan Laboratories, 2012).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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