Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

The toxicokinetic assessment is based upon the available data on bis(4-(1,1,3,3-tetramethylbutyl) phenyl) amine contained within this dossier. Data is taken from reliable sources, all rated as a 2 or higher for reliability and relevance according to the Klimisch scale as identified in Klimisch et al,  1997 scale. The toxicokinetic assessment is therefore considered reliable, based upon the information available.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

The following information on bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine was used for the assessment:

Physical form: powder

Particle size: 404.691 µm (10% <52.296 µm)

Melting point: 98.9 ºC

Boiling point: >400 ºC

Water solubility: 0.1 mg/l at 20 ± 5 ºC

Log Pow: 8.8 at 35 ºC

Vapour pressure: <1.1E-05 Pa at 20 ºC and 25 ºC

Molecular weight: 393.6477

Hydrogen bond donors: 1

Hydrogen bond acceptors: 0

The particle size of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine indicates that it is unlikely to be absorbed via the inhalation route (less than 10% 10µm), and based upon the above information, bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is not expected to be absorbed via the oral route in accordance with Lipinski's rule of five. The low water solubility and high Log Pow of the substance indicate that bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is not easily absorbed in the body. No information is currently available on possible degradation products produced in the gastrointestinal tract. As bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is a solid powder with a very low water solubility (<0.1 mg/l), it is not expected to be absorbed via the dermal route.

During acute toxicity studies no systemic or local effects were noted at doses which humans are likely to come into contact.