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Diss Factsheets
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EC number: 208-793-7 | CAS number: 541-85-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1949
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented non-GLP study for several substances
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List III
- Author:
- Smyth HF. Jr, Carpenter CP., Weil CS
- Year:
- 1 949
- Bibliographic source:
- Journal. Ind. Hyg. and Tox, Issue 1 (31): p60, 1949
Materials and methods
- Principles of method if other than guideline:
- Groups of 5 male albinos rats were given a single dose of 3-heptanone by stomach tube until 2 dosages differing by a multiple of 10 were found, the first one killing some or all of the animals and the other killing some or no animals within 14 days. The chosen concentrations were in a geometric series.
- GLP compliance:
- no
- Remarks:
- Study performed before the introduction of GLP
- Limit test:
- no
Test material
- Reference substance name:
- 3-Heptanone
- IUPAC Name:
- 3-Heptanone
- Reference substance name:
- Heptan-3-one
- EC Number:
- 203-388-1
- EC Name:
- Heptan-3-one
- Cas Number:
- 106-35-4
- Molecular formula:
- C7H14O
- IUPAC Name:
- heptan-3-one
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Sherman or Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Rats weighing ca. 120 g.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- Geometric series of single doses such as 1, 2, 4 and 8 g/Kg body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- approximate LD50
- Effect level:
- 2 760 mg/kg bw
- Mortality:
- Mortality was observed after oral dosing of 3-heptanone and was considered complete 14 days after dosing.
- Clinical signs:
- other: Not determined.
- Gross pathology:
- Not determined.
Any other information on results incl. tables
A fiducial range was also estimated and the LD50 values ranged from 2560 - 2980 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information according to EU GHS or dangerous substance directive Criteria used for interpretation of results: EU
- Conclusions:
- 3-Heptanone is not toxic via an oral exposure according to the EU classification system
- Executive summary:
Acute oral toxicity to rats of 3-heptanone was investigated in a single-dose oral toxicity study. Dosing was performed by oral gavage and mortality was observed for 14 days after dosage. Groups of 5 male animals were used per dose. The calculated LD50 for 3 -heptanone was 2760 mg/kg bw and thus above the classification threshold for acute oral toxicity of 2000 mg/kg bw according to Regulation (EC) 1272/2008 or Directive 67/548/EEC.
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