Registration Dossier
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Diss Factsheets
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EC number: 254-052-6 | CAS number: 38640-62-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature (tables), based on UBA test programme
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: DIN 38412, part 8
- Principles of method if other than guideline:
- Growth inhibition test with the bacterium Pseudomonas putida / Test conducted by WaBoLu; no report available.
- GLP compliance:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- in stock solution only
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: A saturated stock solution (water-accommodated fraction) was prepared by mechanically stirring of excess DIPN per 1 L medium for 48 h followed by separation of the insoluble material from the water phase using pre-conditioned glass fiber filter. The stock solution was diluted with dilution water to the desired concentration. - Test organisms (species):
- Pseudomonas putida
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 16 h
- Test temperature:
- 25 °C
- Nominal and measured concentrations:
- no data
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Aeration: no
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to DIN 38412, part 8
OTHER TEST CONDITIONS
- Adjustment of pH: no
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : growth inhibition
- Duration:
- 16 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 0.16 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Validity criteria fulfilled:
- not specified
- Conclusions:
- No growth inhibition within the range of water solubility.
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract / only short communication, based on UBA test programme
- Principles of method if other than guideline:
- Method: Bioluminescence inhibition assay / test conducted by WaBoLu, BGA/Berlin; no report available.
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Test organisms (species):
- Vibrio fisheri
- Details on inoculum:
- no data
- Test type:
- static
- Water media type:
- saltwater
- Total exposure duration:
- 15 min
- Details on test conditions:
- TEST SYSTEM
no data - Reference substance (positive control):
- not specified
- Duration:
- 15 min
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.1 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- No inhibitory effect within the range of water solubility.
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Principles of method if other than guideline:
- Method: Comparative study programme on the applicability and validation of this test system
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Details on test solutions:
- DIPN was solubilized and finely dispersed in DMSO/medium.
- Test organisms (species):
- Tetrahymena pyriformis
- Details on inoculum:
- no data
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 24 h
- Hardness:
- no data
- Nominal and measured concentrations:
- no data
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- > 0.15 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- No inhibitory effect within the range of solubility
Referenceopen allclose all
No EC50 could be derived, no data available on effects induced
by DIPN.
It can be concluded that DIPN produced no toxicity within
its water solubility.
Documentation in tabular form only.
Description of key information
Diisopropylnaphthalene does not exhibit inhibitory effects on the microorganism tested within its range of water solubility (0.1 to 0.2 mg/L).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 0.15 mg/L
Additional information
For assessment of the toxicity to microorganisms, three studies have been identified. Due to limited reporting (secondary literature or short communication in tabular form), the reliability is 4. As results are very similar, they are used in a weight of evidence approach.
Study |
Test concentration |
Result |
Experimental conditions |
Reliability |
UBA/KBwS 1999 |
no individual test concentrations reported |
EC10: > 0.16 mg/L |
no vehicle |
4 (WoE) |
UBA/KBwS 1999 |
no individual test concentrations reported |
EC50: > 0.1 mg/L |
no vehicle |
4 (WoE) |
Yoshioka 1985 |
no individual test concentrations reported |
EC0: > 0.15 mg/L |
Vehicle: DMSO |
4 (WoE) |
Based on data reported, it is concluded that diisopropylnaphthalene does not exhibit inhibitory effects on the organism tested within its range of water solubility (0.1 to 0.2 mg/L).
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