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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Principles of method if other than guideline:
Basic subacute 28 d repeated dose toxicity study with dermal administration of test substance
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(isopropyl)naphthalene
EC Number:
254-052-6
EC Name:
Bis(isopropyl)naphthalene
Cas Number:
38640-62-9
Molecular formula:
C16H20
IUPAC Name:
bis(isopropyl)naphthalene
Details on test material:
- Name of test material (as cited in study report): R-300 (Diisopropylnaphthalene)
- no further information on test substance

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on exposure:
Route of administration: dermal; test substance was applied on shaved skin of the back of rats (no further information)
Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
28 d
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
not specified
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified

Examinations

Observations and examinations performed and frequency:
CAGE SIDE OBSERVATIONS: No data

DETAILED CLINICAL OBSERVATIONS: No data

BODY WEIGHT: Yes
- Time schedule for examinations: daily

FOOD CONSUMPTION: Yes
- Time schedule for examinations: daily

FOOD EFFICIENCY: No data

WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No data

OPHTHALMOSCOPIC EXAMINATION: No data

HAEMATOLOGY: Yes
- Time schedule for collection of blood: before the start and at the end of the experiment
- Anaesthetic used for blood collection: No data
- Animals fasted: No data
- How many animals: No data
- Parameters examined: conventional hematological parameters

CLINICAL CHEMISTRY: Yes
- Time schedule for collection of blood: before the start and at the end of the experiment
- Animals fasted: No data
- How many animals: No data
- Parameters examined: total serum protein, blood urea nitrogen (BUN), serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), no further information

URINALYSIS: Yes
- Time schedule for collection of urine: before the start and at the end of the experiment
- Metabolism cages used for collection of urine: No data
- Animals fasted: No data
- Parameters examined: conventional urinary examination

NEUROBEHAVIOURAL EXAMINATION: No data
Sacrifice and pathology:
GROSS PATHOLOGY: Yes, complete autopsy; various organ weights were determined.
HISTOPATHOLOGY: Yes

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
385 mg/kg bw/day
Sex:
not specified
Basis for effect level:
other: no data

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
In a dermal 1 month repeated dose toxicity study, a NOAEL of 385 mg/kg bw/day was derived for DIPN under the test conditions used.