Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 223-981-9 | CAS number: 4151-51-3
Endpoint summary
Administrative data
Description of key information
Additional information
In accordance with column 2 of REACH Annex IX, the bioaccumulation in aquatic species study does not need to be conducted as direct or indirect exposure of the aquatic compartment does not occur.
Further according to REACH Annex IX, 9.3.2, column 2 the bioaccumulation study does not need to be conducted if the substance has a low potential for bioaccumulation. Due to the high reactivity of the isocyanates with water, bioaccumulation tests can in principle not be performed with these substances. Rapid hydrolysis of the substance (and isocyanates in general) makes approximation of equilibrium in the environment impossible resulting in a low potential for bioaccumulation.
The hydrolysis products are mainly insoluble, inert oligomeric and polymeric ureas and thus not bioavailable. Theoretically the corresponding amine can be regarded which however is not formed in significant concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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