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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
26 Jul 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Water solubility:
> 250 g/L
Temp.:
20 °C
pH:
5.4

Preliminary test:

Aliquot

Weighed sample, g

A

2.46

B

2.03

Sum

4.49

While being added to the water, solutions with increasing viscosity were being formed, resulting in a gel after the addition of 4.49 g of the test item.

With 4.49 g of test item being mixed into 10 g of water, a gel with a total weight of 14.5 g has been formed. This is equivalent to 31% (w/w) of test item in solution/gel.

As the water density will significantly increase with addition of the test item, it can be concluded that water solubility is about 310 g/L, resulting in a gel. Due to the fact that the formation of the gel is a continuous process and no discrete point can be identified at which dissolution in water switches to gelling, the water solubility can be approximated to > 310 g/L.

Conclusions:
Interpretation of results (migrated information): miscible

Description of key information

> 250 g/L at 20 °C, pH = 5.4

Key value for chemical safety assessment

Additional information

The water solubility of the substance was determined according to EU Method A.6 and OECD 105 (flask method). Gel formation at concentrations > 310 g/L was observed.