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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study without detailed documentation

Data source

Reference
Reference Type:
other: Summary report
Title:
Unnamed
Year:
2008
Report date:
2008

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Qualifier:
according to guideline
Guideline:
EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of (2Z)-2-cyano-2-[3-[(2-ethylhexyl)amino]-5,5-dimethyl-2-cyclohexen-1-ylidene]acetic acid ethyl ester and (2E)-2-cyano-2-[3-[(2-ethylhexyl)amino]-5,5-dimethyl-2-cyclohexen-1-ylidene]acetic acid ethyl ester
EC Number:
700-685-2
Cas Number:
1243654-84-3
Molecular formula:
C21 H34 N2 O2
IUPAC Name:
Reaction mass of (2Z)-2-cyano-2-[3-[(2-ethylhexyl)amino]-5,5-dimethyl-2-cyclohexen-1-ylidene]acetic acid ethyl ester and (2E)-2-cyano-2-[3-[(2-ethylhexyl)amino]-5,5-dimethyl-2-cyclohexen-1-ylidene]acetic acid ethyl ester
Test material form:
not specified
Details on test material:
Please refer to confidential details on test material.

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Janvier, Le Genest-Saint-Isle, France
- Age at study initiation: 8 weeks old
- Weight at study initiation: 191-201 g on day 1

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
corn oil
Doses:
300 and 2000 mg/kg bw (10 mL/kg bw)
No. of animals per sex per dose:
3 rats per dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 8 days
- Frequency of observations and weighing: repeated observation for clinical signs following treatment, then daily; daily weighing
- Necropsy of survivors performed: no data
Statistics:
Not performed

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: There was no mortality.
Mortality:
No deaths occurred.
Clinical signs:
other: 300 mg/kg bw: No clinical signs were observed. 2000 mg/kg bw: Hypoactivity and piloerection were noted in all animals from day 1 until day 2 (1 animal) or day 3 (2 animals). Staggering gait (2 animals) and rhinorrea (all animals) were also observed on day

Applicant's summary and conclusion