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Diss Factsheets

Physical & Chemical properties

Solubility in organic solvents / fat solubility

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solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to guideline
other: - EEC Directive 84/449, A.7
GLP compliance:
standard fat
HB 307, batch 24/11
3.24 other: g/100g of fat
37 °C
Remarks on result:
other: Standard deviation: 0.16g/100g fat
Test substance stable:

Individual results:

Stirring period at 37 °C (h)

Fat solubility in g/100 g of fat

1 hour preequilibration at

30 °C 50 °C
5 3.38 / 3.32 3.46 / 3.46
24 3.10 / 3.03 3.17 / 3.17
48 3.10 3.17

There are no significant differences among the results of preequilibration at 30 °C and 50 °C. The solubility at 37 °C can be taken as the mean value of the ten individual results.

Fat solubility of test substance was determined to be 3.24 g/100 g of fat at 37°C
Executive summary:

In this guideline (EU A. 7) study, the fat solubility of the test material (EC 404-360-3) was determined to be 3.24 g/100 g of fat at 37°C

Description of key information

Study conducted to recognised testing guidelines

Key value for chemical safety assessment

Solubility in mg/100g standard fat:
3 240
At the temperature of:
37 °C

Additional information

3240 mg/100g of fat at 37°C