2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1989

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: - EEC Directive 84/449, A.7

GLP compliance:

no

Medium:

standard fat

Remarks:

HB 307, batch 24/11

Solubility:

3.24 other: g/100g of fat

Temp.:

37 °C

Remarks on result:

other: Standard deviation: 0.16g/100g fat

Test substance stable:

yes

Individual results:

Stirring period at 37 °C (h)	Fat solubility in g/100 g of fat 1 hour preequilibration at
	30 °C	50 °C
5	3.38 / 3.32	3.46 / 3.46
24	3.10 / 3.03	3.17 / 3.17
48	3.10	3.17

There are no significant differences among the results of preequilibration at 30 °C and 50 °C. The solubility at 37 °C can be taken as the mean value of the ten individual results.

Conclusions:

Fat solubility of test substance was determined to be 3.24 g/100 g of fat at 37°C

Executive summary:

In this guideline (EU A. 7) study, the fat solubility of the test material (EC 404-360-3) was determined to be 3.24 g/100 g of fat at 37°C

Description of key information

Study conducted to recognised testing guidelines

Key value for chemical safety assessment

Solubility in mg/100g standard fat:

3 240

At the temperature of:

37 °C

Additional information

3240 mg/100g of fat at 37°C