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Environmental fate & pathways

Biodegradation in water: screening tests

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biodegradation in water: ready biodegradability
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 May to 12 June 2008
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study
according to guideline
OECD Guideline 301 A (Ready Biodegradability: DOC Die Away Test)
not specified
GLP compliance:
not specified
Oxygen conditions:
Inoculum or test system:
activated sludge, non-adapted
Details on inoculum:
The inoculum was prepared from activated sludge taken from a waste water treatment plant (Klagshamn, Sweden). The activated sludge contained 5.9g/L suspended solids.
Duration of test (contact time):
28 d
Initial conc.:
68 mg/L
Based on:
test mat.
Reference substance:
acetic acid, sodium salt
Key result
% degradation (DOC removal)
ca. 4
St. dev.:
Sampling time:
14 d
Remarks on result:
other: Replicate 1: 4%, Replicate 2: 4%
Key result
% degradation (DOC removal)
ca. 84
St. dev.:
Sampling time:
21 d
Remarks on result:
other: Replicate 1: 70%, Replicate 2: 98%
Key result
% degradation (DOC removal)
ca. 93
St. dev.:
Sampling time:
28 d
Remarks on result:
other: Replicate 1: 94%, Replicate 2: 92%
Validity criteria fulfilled:
OECD 301, Readily biodegradable if, 1. DOC removal >70% within 28d 2. 10d window was achieved and ended within 28d
Interpretation of results:
readily biodegradable
The substance cyclic trimethylolpropane formal (CTF) is readily biodegradable.
Executive summary:

The biodegradability of cyclic trimethylolpropane formal (CTF) was determined according to OECD guideline 301A (DOC Die away test). The amount of biodegradation observed comprised 4% after 14 days but increased to 84% after 21 days. CTF can therefore be classified as readily biodegradable and passing the 10 day window.

Description of key information

One key study is presented. This study demonstrates that the test substance Cyclic trimethylolpropane formal (CTF) has been found to the readily biodegradable.

Key value for chemical safety assessment

Biodegradation in water:
readily biodegradable
Type of water:

Additional information

The test substance 5-ethyl-1,3-dioxane-5-methanol has been found to the readily biodegradable with >90% removal after 28 days in both the key and supporting studies. As such removal in the environment is expected to be rapid and complete.