Registration Dossier
Registration Dossier
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EC number: 201-321-0 | CAS number: 81-07-2
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
NOEC was considered to be 2500 mg/l when 451 Danio sp. (Danio) Zebrafish embryo(s)treated with Saccharin for 144 hours post fertilization.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2 500 mg/L
Additional information
In a long term toxicity study, 451 Danio sp. (Danio) Zebrafish embryo(s) were treated with Saccharin.
Embryo(s) and larva were observed for highest non-teratogenic concentration (HNTC), spontaneous tail coilings in zebra fish embryos and eleutheroembryonic and larval locomotor activityfor 144 hours post fertilization.
No effect were observed on highest non-teratogenic concentration (HNTC), spontaneous tail coilings in zebra fish embryos and eleutheroembryonic and larval locomotor activityfor 144 hours post fertilizationofEmbryo(s) and larva of treated fish as compared to control.
Therefore, NOEC was considered to be 2500 mg/l when 451 Danio sp. (Danio) Zebrafish embryo(s)treated with Saccharin for 144 hours post fertilization.
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