Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-606-3 | CAS number: 96690-74-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
3h EC50 (activated sludge, domestic) = 135 mg/L (respiration inhibition test, similar to OECD 209).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 135 mg/L
Additional information
Since no reliable studies on toxic effects of C8-14AS NH4 & TEA (CAS 96690-74-3) to microorganisms are available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5, a read-across to other structurally related category members was conducted.
The key study was performed with C12AS Na (CAS 151-21-3) using activated sludge from a municipal sewage treatment plant (Dutka 1983). The non-GLP test was performed according to a guideline similar to OECD 209. The EC50 values of 188 and 135 mg/L (nominal concentrations) were obtained for the endpoint respiration inhibition after 30 minutes and 3 hours of exposure, respectively. The 3-hour EC50 value of 135 mg/L is the lowest value available and therefore was used for the PNEC STP derivation of C8-14AS NH4 & TEA (CAS 96690-74-3). In the supporting non-GLP study with CAS 151-21-3, Dutka and Kwan (1984) used synthetic activated sludge and measured respiration rate after 3 hours. The 3h IC50 value was 480 mg/L (nominal concentration). Moreover, a GLP test according to DIN 38412 part 8 with Pseudomonas putida using C12-14AS TEA (CAS 90583-18-9) is available (Guhl 1992). In this study, the growth inhibition of Pseudomonas putida was recorded after approximately 16 hours of exposure. The 16-h EC10 value was determined to be 1084 mg a.i./L (nominal concentration).
Due to structural and property similarities with the tested category members it can be concluded that the above results apply also to C8-14AS NH4 & TEA (CAS 96690-74-3).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
