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Diss Factsheets

Physical & Chemical properties

Particle size distribution (Granulometry)

Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2011

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Qualifier:
according to guideline
Guideline:
other: CIPAC MT 187
GLP compliance:
yes
Type of method:
Laser scattering/diffraction
Type of distribution:
other: laser diffraction

Test material

Constituent 1
Chemical structure
Reference substance name:
Nadide
EC Number:
200-184-4
EC Name:
Nadide
Cas Number:
53-84-9
Molecular formula:
C21H27N7O14P2
IUPAC Name:
nadide
Details on test material:
- Substance type: organic
- Physical state: off-white crystalline powder

Results and discussion

Mass median aerodynamic diameter:
ca. 172.799 µm
Particle sizeopen allclose all
Key result
Percentile:
D50
Mean:
ca. 136.609 µm
Remarks on result:
other: Standard deviation not reported
Key result
Percentile:
D10
Mean:
ca. 27.062 µm
Remarks on result:
other: Standard deviation not reported
Key result
Percentile:
D90
Mean:
ca. 361.884 µm
Remarks on result:
other: Standard deviation not reported

Any other information on results incl. tables

Full Test Results

 

RUN 1

RUN 2

RUN 3

RUN 4

RUN 5

**Average

Volume weighted Mean

167.462

169.634

171.443

169.610

170.364

169.702

Median (d.50)

135.600

135.899

136.259

137.516

137.760

136.609

Mode (µm)

197.726

198.720

185.494

198.914

186.765

193.431

*MMAD

171.522

171.900

172.355

173.945

174.254

172.799

10 % of material is <

26.743

27.364

27.184

27.083

26.956

27.062

50 % of material is <

135.600

135.899

136.259

137.516

137.760

136.609

90 % of material is <

355.941

361.974

368.761

360.447

362.668

361.884

All results are in µm

* Mass Median Aerodynamic Diameter

** Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.

2.86 % by volume of sample was seen to be < 10.00 Um

Applicant's summary and conclusion

Conclusions:
Average (µm)
Volume weighted mean 169.702
Median (d.50) 136.609
Mode 193.431
MMAD (Mass Median Aerodynamic Diameter) 172.799
10 % of material is < 27.062
50 % of material is < 136.609
90 % of material is < 361.884
Executive summary:

Both visual microscope and laser diffraction test were conducted to determine the particle size analysis of Nadide powder. The study was conducted in accordance with ISO 13320:2009. For the full solubility and dispersability test, silicone oil was selected. The sample proved to be insoluble and well dispersed in silicone oil, therefore it was chosen as the suspension fluid.

The particle size was analysed over the range 0.02 Um to 2000 Um. The Mass Median Aerodynamic Diameter (MMAD) was 172.799 Um.