Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 14 June 1993 to 27 May 1994
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report Date:
1994

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
Deviations:
not specified
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Batch n. C103330. CH20512
Purity: 99.9%
Expiry May 1996
Appaerance: white powder
Storage conditions: room temperature
Radiolabelling:
no

Study design

Analytical monitoring:
yes
Estimation method (if used):
HPLC
Duration of test
Duration:
5 h
pH:
5
Initial conc. measured:
1 500 µg/L

Results and discussion

Transformation products:
yes
Identity of transformation products
No.:
#1
Reference
Reference substance name:
Unnamed
IUPAC name:
atrazine 2 hydroxy
Identifier:
common name
Identity:
atrazine 2 hydroxy
Total recovery of test substance (in %)open allclose all
% Recovery:
57.25
pH:
5
Temp.:
50 °C
Duration:
5 h
% Recovery:
64.55
pH:
5
Temp.:
60 °C
Duration:
5 h
% Recovery:
45.28
pH:
5
Temp.:
70 °C
Duration:
5 h
Dissipation DT50 of parent compoundopen allclose all
pH:
5
Temp.:
60 °C
Hydrolysis rate constant:
0.11 d-1
DT50:
6.6 d
Type:
(pseudo-)first order (= half-life)
pH:
5
Temp.:
70 °C
Hydrolysis rate constant:
0.19 d-1
DT50:
3.7 d
Type:
(pseudo-)first order (= half-life)
pH:
5
Temp.:
25 °C
Hydrolysis rate constant:
0.01 d-1
DT50:
69.6 d
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: rate costant and half time for 25°C are derived from the 60 and 70°C values.

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Remarks:
No peaks at the characteristic retention volume of the test substance were obtained in the chromatograms of the blank solutions, indicating that the analytical procedure was free from interferences.