Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 14 june 1993 to 13 October 1993
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1994
Report Date:
1994

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
not specified
Qualifier:
according to
Guideline:
other: EPA OPP guideline 63-11
Deviations:
not specified
GLP compliance:
yes
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Atrazine (pure grades)
Batch number 744
Purity 99.5%
Expiry: Stable until at least January 2995
Storage 4°C
Appaerance: white powder

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
2.59
Temp.:
20 °C
pH:
7.31 - 7.51
Details on results:
calibration data show ed a slop of 449576, an intercept of 7301 and a correlation coefficient of 0.99860. Thus, the response of the instrument was shown to be linear over the calibration range used.
The assessment of the reproducibility of the analysis was performed doing seven injection of a calibration solution that produced a mean area of 1200714, with a standard deviation of 6580.9 and a coefficient of variation of 5%.
Standard deviation of individual P values about the mean is 14.034

Applicant's summary and conclusion

Conclusions:
the partition coefficient ( n-octanol/water) of atrazine (pure) has been determined as:
Log P = 2.59 at 20°C