Registration Dossier
Registration Dossier
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EC number: 200-741-1 | CAS number: 70-55-3
Endpoint summary
Administrative data
Description of key information
Additional information
Two acute studies for fish are available. For fish rainbow trout (Salmo gairdneri) was most sensitive with a 96h-LC50 of 102 mg/L, nominal concentration.
No valid acute studies on invertebrates and algae are available for p-Toluenesulfonamide. Read across is performed with o-Toleunesulfonamide (CAS 88 -19 -7).
The EC50 (48h) for invertebrates (Daphnia magna)
of o-Toluenesulfonamide was 210 mg/L, based on nominal concentrations.The ErC50 for algae (Pseudokirchneriella subcapitata)
for o-Toluenesulfonamide were 170 mg/L, based on measured concentrations.
No valid long-term studies are available for p-Toluenesulfonamide. Read across is performed with o-Toleunesulfonamide (CAS 88 -19 -7).
The long-term study with invertebrates (Daphnia magna) for o-Toleunesulfonamide gave a NOEC (21d) and EC50 (21d) for reproduction of 49 and 79 mg/L, respectively, based measured (TWA) concentrations.
The 72h-NOEC (based on growth rate) for algae (Pseudokirchneriella subcapitata)
with o-Toleunesulfonamide was 7.7 mg/L, based on measured concentrations.
One study, valid without restrictions, is available with Chloramine T (CAS 127 -65 -1)
(Geerts, 2012). As Chloramine T is instantly converted to p-TSA in the presence of organic material, this study can be used for p-TSA as well. Toxicity to microorganisms was determined according to OECD Guideline 209 and the 3h-EC10 was found to be 14 mg/L (nominal). The 3h-EC50 was 37 mg/L (nominal). Converted to p-TSA the 3h-EC10 and and 3h-EC50 are 10.5 mg/L and 27.8 mg/L, respectively.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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