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EC number: 200-741-1 | CAS number: 70-55-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was performed pre-GLP. Alike OECD 404, but with some deviations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. FDA (Fed. Reg. 28 (119), 5582, 1963)
- Principles of method if other than guideline:
- - exposure period 24 hours
- rabbit skin is exposed under occlusion
- the test substance is not moistened to ensure optimal skin contact
- the animal skin is exposed intact (6 animals) and abraded (6 animals)
- it cannot be assessed if/when effects are reversible. Observation were made up to 72 hour after exposure.
- no details on test animals and their accomodation - GLP compliance:
- no
- Remarks:
- pre-GLP
Test material
- Reference substance name:
- Toluene-4-sulphonamide
- EC Number:
- 200-741-1
- EC Name:
- Toluene-4-sulphonamide
- Cas Number:
- 70-55-3
- Molecular formula:
- C7H9NO2S
- IUPAC Name:
- 4-methylbenzene-1-sulfonamide
- Reference substance name:
- p-Toluenesulfonamide
- IUPAC Name:
- p-Toluenesulfonamide
- Test material form:
- solid: crystalline
- Details on test material:
- Name: para toluenesulfonamide
Appearance: a white solid
Date received: 15 March 1978
No further data
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: no data
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5g - Duration of treatment / exposure:
- 24 hours
- Observation period:
- The skin is evaluated 24 and 72 hours after the start of exposure.
- Number of animals:
- 6 with intact and 6 with abraded skin
- Details on study design:
- TEST SITE
- Area of exposure: back of the animal
- % coverage: 2.5x2.5 cm
- Type of wrap if used: Surgical patch measuring 1 inch x 1 inch (2.5 x2.5 cm). The patches are fixed to the application site by means of adhesive tape and the entire trunk of the rabbits is wrapped with an impervious material.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): none
- Time after start of exposure: not applicable
SCORING SYSTEM: Draize
Erythema and eschar formation
0 No erythema
1 Very slight erythema (barely perceptible)
2 Well defined erythema
3 Moderate to severe erythema
4 Severe erythema (beet redness) to slight eschar formation (injuries in depth)
Oedema formation
0 No oedema
1 Very slight edema(barely perceptible)
2 Slight edema(edges of the area well defined by definite raising)
3 Moderate edema(raised approximately 1mm)
4 Severe edema( raised more than 1 mm and extending beyond the area of exposure)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24-72 hours
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: intact + abraded skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24-72 hours
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: intact + abraded skin
- Irritant / corrosive response data:
- after 24 hours: Highest score: very slight erythema, no oedema
after 72 hours: Highest score: very slight erythema, no oedema
No difference was observed between intact and abraded skin
Any other information on results incl. tables
Results
Rabbit No and sex |
Hours after instillation |
Average 24-72 hours: Intact |
Rabbit No and sex |
Hours after instillation |
Average 24-72 hours: Abraded |
|||
Site |
24 |
72 |
24 |
72 |
||||
7247 |
erythema |
1 |
0 |
0.5 |
7241 |
0 |
0 |
0 |
oedema |
0 |
0 |
0 |
0 |
0 |
0 |
||
7248 |
erythema |
D |
D |
D |
7242 |
1 |
0 |
0.5 |
oedema |
D |
D |
D |
0 |
0 |
0 |
||
7249 |
erythema |
0 |
0 |
0 |
7243 |
1 |
0 |
0.5 |
oedema |
0 |
0 |
0 |
0 |
0 |
0 |
||
7250 |
erythema |
0 |
0 |
0 |
7244 |
1 |
0 |
0.5 |
oedema |
0 |
0 |
0 |
0 |
0 |
0 |
||
7251 |
erythema |
1 |
0 |
0.5 |
7245 |
1 |
0 |
0.5 |
oedema |
0 |
0 |
0 |
0 |
0 |
0 |
||
7252 |
erythema |
0 |
1 |
0.5 |
7246 |
1 |
1 |
1 |
oedema |
0 |
0 |
0 |
0 |
0 |
0 |
D = dead
Highest grade observed: very slight erythema, no oedema
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The results show that the test substance is very slightly irritating to skin. It causes minimal erythema and no oedema. The contact time is too long but the test substance was not moistened so contact with the skin may not have been optimal. Reversibility cannot be assessed but the effects are of such minimal nature that full reversibility is expected well within 14 days. Although this study has deviations performing a new study is not warranted because it will not provide any new information. With this study it has been shown that the substance is not a skin irritant according to GHS.
- Executive summary:
The primary irritation of p-TSA to the skin is measured by a occlusive patch-test technique on the abraded and intact skin of albino rabbits. The study was performed according to methods similar to OECD404. but with the following deviations:
- exposure period 24 hours
- rabbit skin is exposed under occlusion
- the test substance is not moistened to ensure optimal skin contact
- the animal skin is exposed intact and abraded
- it cannot be assessed if/when effects are reversible. Observations were made up to 72 hour after exposure.
- no details on test substance identity or composition
- no details on test animals and their accommodation
Twelve healthy adult New Zealand White albino rabbits are used. Twenty four hours prior to applying the materials, the hair is removed from the backs of the animals with an electric clipper in such a way as to avoid abrasions. An amount of 0.5 g is placed on the skin under occlusion for 24 hours. The skin is evaluated 24 and 72 hours after the start of exposure. After 24 hours: very slight erythema after 72 hours: very slight erythema. No difference was observed between intact and abraded skin.
The results show that the test substance is very slightly irritating to skin. It causes minimal erythema (Very slight erythema - barely perceptible)
and no oedema. The contact time is too long but the test substance was not moistened so contact with the skin may not have been optimal. Reversibility cannot be assessed but the effects are of such minimal nature that full reversibility is expected well within 14 days. Although this study has many deviations performing a new study is not warranted because it is not expected to provide any new information. With this study it has been shown that the substance is not a skin irritant according to GHS.
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