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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment. Toxicity report giving very brief summary of this and other studies.

Data source

Reference
Reference Type:
publication
Title:
Respiratory retention and acute toxicity of furan
Author:
Egle JL; Gochberg BJ
Year:
1979
Bibliographic source:
Am Ind. Hyg. Assoc. 40, 310-314

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no
Test type:
fixed concentration procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Furan
EC Number:
203-727-3
EC Name:
Furan
Cas Number:
110-00-9
Molecular formula:
C4H4O
IUPAC Name:
furan
Details on test material:
No data.

Test animals

Species:
mouse
Strain:
Swiss
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 18-21 grams


Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
not specified
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- System of generating particulates/aerosols: The furan used in the study was generated for inhalation by passing air through pure furan at room temprature. The vapour, in concentrated form was then transferred using 100 cc siliconized glass syringe to a 5.2 litre sealed glass desiccator containing 3 or 4 mice.


TEST ATMOSPHERE
- Brief description of analytical method used: Air samples containing the test substance were drawn from into syringes and analyzed in a GC. A 0.2ul aliquot of the vapour in solvent was injected into a Chromosob W column. Peak area was the main method used in compound identification and concnetration of vapour.
- Samples taken from breathing zone: yes

Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
1 h
Concentrations:
0.03 ug/mL to 1.0 ug/mL
No. of animals per sex per dose:
3-4
Control animals:
not specified
Details on study design:
No data

Results and discussion

Effect levels
Dose descriptor:
LC50
Effect level:
0.12 other: ug/ml
Remarks on result:
other: (0.11-0.13)
Clinical signs:
other: Those mice that did not survive became hyperactive for periods of 10 to 15 minutes, then their breathing laboured, and they died soon after.
Gross pathology:
Examination of the lungs revealed inflammation and fluid accumulation.

Applicant's summary and conclusion

Conclusions:
A very limited summary of a non-guideline, non-GLP study, recorded a 1-hour LC50 of 0.12 mg/l in small groups of mice exposed the furan vapour.