Registration Dossier
Registration Dossier
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EC number: 203-727-3 | CAS number: 110-00-9
Endpoint summary
Administrative data
Description of key information
No reliable studies were identified on the effects of furan on the skin or eyes; no studies have been entered into IUCLID.
Key value for chemical safety assessment
Additional information
Human Toxicity
A published review describing potential human effects notes that furan can “burn the skin and eyes” and that the vapour “can irritate the respiratory tract” (Pohanish, 2008).
The IARC monograph on furan notes that the occupational exposure limit for furan in the Russian Federation included a notation of skin irritancy (ILO, 1991).
Animal studies
A databank (HSDB, 2011) reports irritation when furan was applied at 1-50% to the skin of guinea pigs (Chernousov, 1974). No further details are given.
REFERENCES
Chernousov AD (1974). [Allergenic properties of furan compounds.] Gig Sanit 6, 28-32 (as cited in HSDB, 2011).
HSDB (2011). Hazardous Substances Data Bank. Databank Number 89, last revised 16 June 2011.http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~lMMQU6:1
ILO (1991). Occupational Exposure Limits for Airborne Toxic Substances: Values of Selected Countries. Occupational Safety and Health Series No. 37, 3rd Ed.,, p206-207 (as cited in WHO, 1995).
Pohanish, R.P (ed) (2008). Sittig’s Handbook of Toxic and Hazardous Chemical Carcinogens, 4th Edition Volume 1: A-H; p1194-1196.
WHO (1995). IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-present. Vol 63, 393-407.http://monographs.iarc.fr/ENG/Monographs/vol63/mono63-16.pdf
Justification for classification or non-classification
Furan is classified Skin Irritation 2; H315: causes skin irritations (Regulation (EC) 1272/2008).
It is unclear from the data reported here how the current classification was derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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