Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

In a study from Brooke et al. (1984) a 96h LC50 of 61 mg/l has been determined for the effects of furan on mortality of the freshwater fish Pimephales promelas, based on measured concentrations. Another short-term study reports a 48 h EC50 value of 71 mg/l on behaviour and equilibrium effects of furan on P. promelas (Call. et al. 1981, as cited in US EPA database). The Japanese Ministry of Environment (MoE, 2010a) reports a 96 h LC50 value of >120 mg/L with Oryzias latipes.

A long-term toxicity fish study with P. promelas derived a 31-33 day NOEC value of 8.3 mg/l (measured concentration) based on one or more parameters of hatchability, larval development, survival or growth (Call et al. 1985). A study from Call and Geiger (1992, as cited in US EPA database) reports a 33 d NOEC value of 36 mg/l based on mortalities of P. promelas.

A short-term toxcity to invertebrates and algal inhibition study have been conducted by the Japanese MoE (2010b, c) determining EC50 values of >58 mg/l and 110 mg/l respectively, with Daphnia magna and Pseudokirchneriella subcapitata respectively. The studies have been conducted according to OECD guidelines 202 and 201 and in compliance with GLP.

No data are available concerning the long-term toxicity of furan to invertebrates, or toxicity to sediment organisms.

References:

Brooke, L.T., Call, D.J. Geiger, D.L. and Northcott, C.E. (1984) Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Vol. 1, Center for Lake Superior Environmental Studies, University of Wisconsin-Superior, Superior, WI; p.414

Call, D.J. Brooke, L.T. Ahmad, N. and Vaishnav, D.D. (1981) Aquatic Pollutant Hazard Assessments and Development of a Hazard Prediction Technology by Quantitative Structure-Activity Relationships. Second Quarterly Rep., U.S.EPA Coop.Agreement No.CR 809234-01-0, Ctr.for Lake Superior Environ.Stud., Univ.of Wisconsin, Superior, WI; p.74 (as cited in US EPA database).

Call, D.J. Brooke, L.T. Knuth, M.L. Poirier, S.H. and Hoglund, M.D. (1985) Fish subchronic toxicity prediction model for industrial organic chemicals that produce narcosis. Environmental Toxicology and Chemistry, 4: 335 -341.

Call, D.J. and Geiger, D.L. (1992) Subchronic Toxicities of Industrial and Agricultural Chemicals to Fathead Minnows (Pimephales promelas). Volume 1. Center for Lake Superior Environmental Studies, University of Wisconsin, Superior, WI; p.318

MOE - Ministry of Environment (2010a) Acute toxicity to fish. Study number 95035. Report number: 662 -09 -E-5035. Report date: 2010-02-12. No further details on the source are available because the source is in Japanese.

MOE - Ministry of Environment (2010b) Acute toxicity to Daphnia. Study number 95034. Report number: 662-09-E-5034. Report date: 2012-02-10. No further details on the source are available because the source is in Japanese.

MOE - Ministry of Environment (2010c) Algal inhibition study. Study number 95033. Report number: 662-09-E-5033. Report date: 2012-02-15. No further details on the source are available because the source is in Japanese.

US EPA ECOTOX online Database System. Accessed via http://cfpub.epa.gov/ecotox/