Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 203-737-8 | CAS number: 110-12-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Guidance on Safe Use
Administrative data
First-aid measures
Description of first-aid measures
If inhaled:
- Move to fresh air.
- Treat symptomatically.
- If symptoms persist, call a physician.
In case of skin contact:
- Wash off with soap and plenty of water.
- Remove contaminated clothing and shoes.
- Get medical attention if symptoms occur.
- Wash contaminated clothing before reuse.
In case of eye contact:
- In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
- If easy to do, remove contact lens, if worn.
If swallowed:
- Seek medical advice.
Most important symptoms and effects, both acute and delayed:
- None known.
Fire-fighting measures
Extinguishing media
Suitable extinguishing media:
- Water spray
- Dry chemical
- Carbon dioxide (CO2)
- Foam
Unsuitable extinguishing media:
- Do not use a solid water stream as it may scatter and spread fire.
Special hazards arising from the substance or mixture
Specific hazards during fire fighting:
- Flash back possible over considerable distance.
- Prevent buildup of vapors or gases to explosive concentrations.
- Forms peroxides of unknown stability.
Hazardous combustion products:
- No hazardous combustion products are known
Advice for firefighters
Special protective equipment for fire-fighters:
- Wear an approved positive pressure self-contained breathing apparatus in addition to standard fire fighting gear.
Further information:
- Flammable liquid and vapour.
- Material will float and may ignite on surface of water.
- Use a water spray to cool fully closed containers.
Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal precautions:
- Wear appropriate personal protective equipment.
- Local authorities should be advised if significant spillages cannot be contained.
Environmental precautions
Environmental precautions:
- Avoid release to the environment.
Methods and material for containment and cleaning up
Methods for cleaning up:
- Contain spillage, soak up with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite)
and transfer to a container for disposal according to local / national regulations (see section 13).
- Eliminate all ignition sources if safe to do so.
- Prevent runoff from entering drains, sewers, or streams.
- After cleaning, flush away traces with water.
- Eliminate all ignition sources if safe to do so.
Handling and storage
Precautions for safe handling
Advice on safe handling:
- Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- Ground and bond container and receiving equipment.
- Use explosion-proof electrical equipment.
- Use non-sparking tools.
- Take precautionary measures against static discharges.
- Do not breathe vapors or spray mist.
- Use only with adequate ventilation.
- Avoid prolonged or repeated contact with skin.
- Wash thoroughly after handling.
- Minimize exposure to air.
- After opening, purge container with nitrogen before reclosing.
- Periodically test for peroxide formation on long-term storage.
Advice on protection against fire and explosion:
- None known.
Hygiene measures:
- Handle in accordance with good industrial hygiene and safety practice.
Conditions for safe storage, including any incompatibilities
Requirements for storage areas and containers:
- Keep container tightly closed and in a well-ventilated place.
- Keep away from heat and sources of ignition. Protect against light.
Specific end use(s)
Specific use(s):
- Chemical intermediate
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- UN 2302
Shipping information
- Proper shipping name and description:
- UN 2302 5-methylhexan-2-one
- Chemical name:
- 5-methylhexan-2-one
- Packing group:
- Packing group III: Substances presenting low danger
- Labels:
- 3
SpecialProvisionsopen allclose all
Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- UN 2302
Shipping information
- Proper shipping name and description:
- UN 2302 5-methylhexan-2-one
- Chemical name:
- 5-methylhexan-2-one
- Packing group:
- Packing group III: Substances presenting low danger
- Labels:
- 3
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- 3 UN 2302 III
Shipping information
- Proper shipping name and description:
- 5-Methylhexan-2-one
3 UN 2302 III - Chemical name:
- Methyl Isoamyl Ketone
- EmS code:
- F-E
- S-D
- Labels:
- Flammable Liquid
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- 3 UN 2302 III
Shipping information
- Proper shipping name and description:
- 5-Methylhexan-2-one
3 UN 2302 III - Chemical name:
- Methyl Isoamyl Ketone
- Packing group:
- Packing group III: Substances presenting low danger
- Labels:
- Flammable Liquid
Remarksopen allclose all
SpecialProvisionsopen allclose all
Exposure controls / personal protection
Country specific exposure limits have not been established or are not applicable unless listed below.
METHYL ISOAMYL KETONE
TLV-STEL: Threshold Limit Value-Short-Term Exposure Limit: 100 ppm / 475 mg/m³ (Basis: GB EH40)
Further information: Can be absorbed through the skin. The assigned substances are those for which there are concerns that dermal absorption will lead to systemic toxicity.
Time Weighted Average (TWA): 20 ppm / 95 mg/m³ (Basis: 2000/39/EC)
Further information: Indicative
Exposure controls
Engineering measures
Good general ventilation (typically 10 air changes per hour) should be used. Ventilation rates should be matched to conditions. If applicable, use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits. If exposure limits have not been established, maintain airborne levels to an acceptable level.
Personal protective equipment
Eye protection :
- Wear safety glasses with side shields (or goggles).
Hand protection
Remarks:
- Wear suitable gloves.
Respiratory protection:
- If engineering controls do not maintain airborne concentrations below recommended exposure limits (where applicable)
or to an acceptable level (in countries where exposure limits have not been established), an approved respirator must be
worn.
Protective measures:
- Ensure that eye flushing systems and safety showers are located close to the working place.
- Remove respiratory and skin/eye protection only after vapors have been cleared from the area.
- Ensure that eye flushing systems and safety showers are located close to the working place.
- Use personal protective equipment as required.
Stability and reactivity
Reactivity
- Stable
Chemical stability
- Stable under normal conditions.
Possibility of hazardous reactions
Hazardous reactions
- Forms peroxides of unknown stability.
Conditions to avoid
Conditions to avoid
- Heat, flames and sparks.
Incompatible materials
Materials to avoid:
- Oxidizing agents
Hazardous decomposition products
- Carbon dioxide (CO2)
- Carbon monoxide
Disposal considerations
Waste treatment methods
Product:
- Dispose of in accordance with local regulations.
- Mix with compatible chemical which is less flammable and incinerate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
